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Jose SK, Marfatia YS. Erythema elevatum diutinum in acquired immune deficiency syndrome: Can it be an immune reconstitution inflammatory syndrome?. Indian J Sex Transm Dis AIDS. 2016;37(1):81-4doi: 10.4103/0253-7184.180287.
Jose, S. K., & Marfatia, Y. S. (2016). Erythema elevatum diutinum in acquired immune deficiency syndrome: Can it be an immune reconstitution inflammatory syndrome?. Indian journal of sexually transmitted diseases and AIDS, 37(1), 81-4. https://doi.org/10.4103/0253-7184.180287
Jose, Sheethal K, and Marfatia, Yogesh S. "Erythema elevatum diutinum in acquired immune deficiency syndrome: Can it be an immune reconstitution inflammatory syndrome?." Indian journal of sexually transmitted diseases and AIDS vol. 37,1 (2016): 81-4. doi: https://doi.org/10.4103/0253-7184.180287
Jose SK, Marfatia YS. Erythema elevatum diutinum in acquired immune deficiency syndrome: Can it be an immune reconstitution inflammatory syndrome?. Indian J Sex Transm Dis AIDS. 2016 Jan-Jun;37(1):81-4. doi: 10.4103/0253-7184.180287. PMID: 27190420; PMCID: PMC4857691.
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Indian J Sex Transm Dis AIDS. 2016 Jan-Jun;37(1):81-4. doi: 10.4103/0253-7184.180287.

Erythema elevatum diutinum in acquired immune deficiency syndrome: Can it be an immune reconstitution inflammatory syndrome?.

Indian journal of sexually transmitted diseases and AIDS

Sheethal K Jose, Yogesh S Marfatia

Affiliations

  1. Department of Skin-VD, SSG Hospital, Vadodara, Gujarat, India.

PMID: 27190420 PMCID: PMC4857691 DOI: 10.4103/0253-7184.180287

Abstract

A 47-year-old male with acquired immune deficiency syndrome (AIDS) presented with multiple hyperpigmented papules and nodules on both ankles, dorsum of bilateral feet and soles. It was associated with mild itching and pain. The patient was diagnosed with human immunodeficiency virus (HIV) in 2007. First-line antiretroviral therapy (ART) was started in 2009 to which he responded initially. He was shifted to second-line ART 11 months ago in March 2015 due to treatment failure as suggested by CD4 count of 50 cells/mm(3). The present skin lesions started 2 months after the initiation of second-line ART. Differential diagnoses considered were Kaposi's sarcoma and immune reconstitution inflammatory syndrome (IRIS) related infections, but biopsy was suggestive of erythema elevatum diutinum (EED). Patient was started on oral dapsone 100 mg/day and increased to 200 mg/day to which he is responding gradually. In the present case, appearance of the lesions after initiation of second-line ART coupled with increase in CD4 count and decrease of viral load below undetectable level suggest that EED could be an IRIS.

Keywords: EED; HIV/AIDS; IRIS

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