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Evid Based Complement Alternat Med. 2016;2016:3281968. doi: 10.1155/2016/3281968. Epub 2016 Apr 10.

Chinese Herbal Medicine as Adjunctive Therapy to Chemotherapy for Breast Cancer: A Systematic Review and Meta-Analysis.

Evidence-based complementary and alternative medicine : eCAM

Xu Sun, Xing Zhang, Jia-Yun Nian, Jiao Guo, Yi Yin, Gan-Lin Zhang, Ming-Wei Yu, Yi Zhang, Xiao-Min Wang, Guo-Wang Yang, Lin Yang, Pei-Yu Cheng, Jin-Ping Li

Affiliations

  1. Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China.
  2. Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China; Beijing University of Chinese Medicine, Beijing 100029, China.
  3. Department of Oncology, Third Affiliated Hospital of Henan College of Traditional Chinese Medicine, Zhengzhou 450000, China.
  4. Department of Oncology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China; Department of Medical Biochemistry and Microbiology, Uppsala University, 75123 Uppsala, Sweden.

PMID: 27190531 PMCID: PMC4842043 DOI: 10.1155/2016/3281968

Abstract

Chinese herbal medicine (CHM) has been increasingly employed during therapy for breast cancer, but its efficacy remains a matter of debate. This systematic review examined randomized controlled trials to provide a critical evaluation of this treatment. The results demonstrated that the combined use of CHM with chemotherapy may improve the immediate tumor response and reduce chemotherapy-associated adverse events. Our findings highlight the poor quality of Chinese studies, and additional well-designed randomized controlled trials addressing the role of CHM are warranted. The lack of molecular-based evidence for CHM and Zheng has resulted in a limited understanding and acceptance of CHM and traditional Chinese medicine in Western countries. We believe that researchers should immediately explore a CHM-based cure, and CHM should be applied to routine care as soon as conclusive data are available.

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