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Kanodia KV, Vanikar AV, Patel RD, et al. Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years. J Clin Diagn Res. 2016;10(4):EC15-7doi: 10.7860/JCDR/2016/17297.7646.
Kanodia, K. V., Vanikar, A. V., Patel, R. D., Suthar, K. S., Nigam, L. K., Patel, H. V., Kute, V., & Trivedi, H. L. (2016). Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years. Journal of clinical and diagnostic research : JCDR, 10(4), EC15-7. https://doi.org/10.7860/JCDR/2016/17297.7646
Kanodia, Kamal V, et al. "Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years." Journal of clinical and diagnostic research : JCDR vol. 10,4 (2016): EC15-7. doi: https://doi.org/10.7860/JCDR/2016/17297.7646
Kanodia KV, Vanikar AV, Patel RD, Suthar KS, Nigam LK, Patel HV, Kute V, Trivedi HL. Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years. J Clin Diagn Res. 2016 Apr;10(4):EC15-7. doi: 10.7860/JCDR/2016/17297.7646. Epub 2016 Apr 01. PMID: 27190812; PMCID: PMC4866110.
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J Clin Diagn Res. 2016 Apr;10(4):EC15-7. doi: 10.7860/JCDR/2016/17297.7646. Epub 2016 Apr 01.

Collapsing Glomerulopathy: A Single Centre Clinicopathologic Study of Seven Years.

Journal of clinical and diagnostic research : JCDR

Kamal V Kanodia, Aruna V Vanikar, Rashmi D Patel, Kamlesh S Suthar, Lovelesh K Nigam, Himanshu V Patel, Vivek Kute, Hargovind L Trivedi

Affiliations

  1. Professor, Department of Pathology, Lab Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .
  2. Professor and Head, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .
  3. Professor, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .
  4. Associate Professor, Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .
  5. Professor, Department of Nephrology and Transplantation, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .
  6. Associate Professor, Department of Nephrology and Transplantation, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .
  7. Professor, Department of Nephrology and Transplantation Medicine and Director, G.R. Doshi and K.M. Mehta Institute of Kidney Diseases & Research Centre and Dr. H.L. Trivedi Institute of Transplantation Sciences , Civil Hospital Campus, Asarwa, Ahmedabad, India .

PMID: 27190812 PMCID: PMC4866110 DOI: 10.7860/JCDR/2016/17297.7646

Abstract

INTRODUCTION: Collapsing Glomerulopathy (CG) is recognized as distinct pattern of proliferative parenchymal injury with poor response to empirical therapy.

AIM: A single center retrospective study was carried out to find out clinicopathological features of idiopathic CG.

MATERIALS AND METHODS: A total of 3335 native renal biopsies were analyzed retrospectively which were performed from 2008 to 2014 with emphasis on clinicopathological correlation and histopathological presentation.

RESULTS: Idiopathic CG constituted 0.75% incidence (25 out of 3335 biopsies) of all biopsies, adults constituting major study part with 88%. The duration of the symptoms at the time of biopsy was 34.12±26.09 days and 35±22.91 days respectively in adults and children. Hypertension was noted in 9(40.9%) and oliguria in 8(36.4%) in adults. Urinalysis revealed microscopic haematuria 12(54.5%) in adults. Nephrotic range proteinuria was reported in 10 (45.5%) adult patients. Glomerular collapse with hyperplasia/ hypertrophy of podocytes was seen in 4.54±3.11 glomeruli. Tubular microcystic dilation was seen in 16(64%) patients. Tubular atrophy involving mild (t1) in 15(60%), moderate (t2) in 4(16%) and severe (t3) in 6(24%) patients. Interstitial fibrosis was mild (i1) in 17(68%), moderate (i2) in 2(8%) and severe (i3) in 6(24%) patients.

CONCLUSION: Idiopathic CG is a morphological pattern of grave podocyte injury with poor prognosis. However, there are chances of remission/ recovery if the tubular atrophy and interstitial fibrosis are of grades ≤ t1 i1.

Keywords: End stage renal disease; Idiopathic collapsing glomerulopathy; Podocyte; Proteinuria

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