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Neupane S, Dubey RK, Gautam N, et al. Association between serum uric acid, urinary albumin excretion, and glycated hemoglobin in Type 2 diabetic patient. Niger Med J. 2016;57(2):119-23doi: 10.4103/0300-1652.182074.
Neupane, S., Dubey, R. K., Gautam, N., Agrawal, K. K., Jayan, A., Shrestha, S., & Jha, A. C. (2016). Association between serum uric acid, urinary albumin excretion, and glycated hemoglobin in Type 2 diabetic patient. Nigerian medical journal : journal of the Nigeria Medical Association, 57(2), 119-23. https://doi.org/10.4103/0300-1652.182074
Neupane, Sunita, et al. "Association between serum uric acid, urinary albumin excretion, and glycated hemoglobin in Type 2 diabetic patient." Nigerian medical journal : journal of the Nigeria Medical Association vol. 57,2 (2016): 119-23. doi: https://doi.org/10.4103/0300-1652.182074
Neupane S, Dubey RK, Gautam N, Agrawal KK, Jayan A, Shrestha S, Jha AC. Association between serum uric acid, urinary albumin excretion, and glycated hemoglobin in Type 2 diabetic patient. Niger Med J. 2016 Mar-Apr;57(2):119-23. doi: 10.4103/0300-1652.182074. PMID: 27226687; PMCID: PMC4872489.
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Niger Med J. 2016 Mar-Apr;57(2):119-23. doi: 10.4103/0300-1652.182074.

Association between serum uric acid, urinary albumin excretion, and glycated hemoglobin in Type 2 diabetic patient.

Nigerian medical journal : journal of the Nigeria Medical Association

Sunita Neupane, Raju Kumar Dubey, Narayan Gautam, Krishna Kumar Agrawal, Archana Jayan, Sujata Shrestha, Amit Chandra Jha

Affiliations

  1. Department of Biochemistry, Universal College of Medical Sciences, Bhairawaha, Nepal.
  2. Department of Internal Medicine, Universal College of Medical Sciences, Bhairawaha, Nepal.

PMID: 27226687 PMCID: PMC4872489 DOI: 10.4103/0300-1652.182074

Abstract

BACKGROUND: Diabetes mellitus (DM) is a chronic disease characterized by insulin deficiency or peripheral resistance resulting in hyperglycemia. Poor glycemic control leads to diabetic complications. Hyperuricemia has been reported with increased risk of renal insufficiency. The aim of this study was to evaluate the relationship between serum uric acid concentration, degree of urinary albumin excretion (UAE) and glycated hemoglobin (HbA1c) in Type 2 DM (T2DM) patients.

MATERIALS AND METHODS: Serum uric acid concentrations, urine microalbumin, and HbA1c were measured in fifty T2DM patients. We then evaluated relationship between uric acid concentrations, degree of UAE and glycemic control as well as other confounding variables.

RESULTS: Serum uric acid concentration correlated positively with UAE (r = 0.323, P < 0.05), age (r = 0.337, P < 0.05), age at onset (r = 0.341, P < 0.05), and duration of DM (r = 0.312, P < 0.05). Multiple regression analysis demonstrated that serum uric acid concentration (β = 0.293, P < 0.0001), duration of DM (β = 0.261, P < 0.0001), HbA1c (β = 0.173, P < 0.005), and systolic blood pressure (β = 0.268, P < 0.005) were independent determinants of UAE.

CONCLUSIONS: Serum uric acid concentration is associated with microalbuminuria and HbA1c in T2DM patients.

Keywords: Glycated hemoglobin; Type 2 diabetes mellitus; microalbumin; uric acid

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