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Kumar MS, Kumar MH, Vishalakshi K, et al. Radiographic Assessment of Bone Formation Using rhBMP2 at Maxillary Periapical Surgical Defects: A Case Series. J Clin Diagn Res. 2016;10(4):ZR01-4doi: 10.7860/JCDR/2016/11775.7522.
Kumar, M. S., Kumar, M. H., Vishalakshi, K., & Sabitha, H. (2016). Radiographic Assessment of Bone Formation Using rhBMP2 at Maxillary Periapical Surgical Defects: A Case Series. Journal of clinical and diagnostic research : JCDR, 10(4), ZR01-4. https://doi.org/10.7860/JCDR/2016/11775.7522
Kumar, M Siva, et al. "Radiographic Assessment of Bone Formation Using rhBMP2 at Maxillary Periapical Surgical Defects: A Case Series." Journal of clinical and diagnostic research : JCDR vol. 10,4 (2016): ZR01-4. doi: https://doi.org/10.7860/JCDR/2016/11775.7522
Kumar MS, Kumar MH, Vishalakshi K, Sabitha H. Radiographic Assessment of Bone Formation Using rhBMP2 at Maxillary Periapical Surgical Defects: A Case Series. J Clin Diagn Res. 2016 Apr;10(4):ZR01-4. doi: 10.7860/JCDR/2016/11775.7522. Epub 2016 Apr 01. PMID: 27190972; PMCID: PMC4866270.
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J Clin Diagn Res. 2016 Apr;10(4):ZR01-4. doi: 10.7860/JCDR/2016/11775.7522. Epub 2016 Apr 01.

Radiographic Assessment of Bone Formation Using rhBMP2 at Maxillary Periapical Surgical Defects: A Case Series.

Journal of clinical and diagnostic research : JCDR

M Siva Kumar, M Hari Kumar, K Vishalakshi, H Sabitha

Affiliations

  1. Senior Lecturer, Department of Oral and Maxillofacial Surgery, Saveetha Dental College and Hospital , Chennai, Tamil Nadu India .
  2. Former Senior Lecturer - Department of Oral Medicine and Maxillofacial Radiology, Rajas Dental College , Vadakkankulam, Tamilnadu, India .
  3. Clinical Associate & Consultant Orthodontist, Prof. Dr. Kamalkannadasan Maxillofacial Clinic , Saligramam, Chennai, India .
  4. Consultant Dental Surgon, Jeba Dental Clinic , N.O 438a; Kproad, Nagercoil, India .

PMID: 27190972 PMCID: PMC4866270 DOI: 10.7860/JCDR/2016/11775.7522

Abstract

Periapical cysts are the most common inflammatory odontogenic cysts arising from untreated dental caries with pulp necrosis and periapical infection. The choice of treatment is often influenced by various factors like size, extension of the lesion, proximity to vital structures, systemic condition and compliance of the patient too. The treatment protocol for management of periapical cysts is still under discussion and options vary from conservative treatment by means of endodontic technique to surgical treatment like decompression or a marsupialisation or even to enucleation. Large bony defect secondary to periapical surgery compromising the tooth integrity often requires bone graft to enhance bone formation and thus restoring function at the earliest. The present case series included 10 patients who had established periapical pathology secondary to history of trauma on upper anterior teeth as well patients with history of carious teeth with an apparent failure in root canal therapy. All ten patients were treated with cyst enucleation and apiceotomy along with 1.4cc Recombinant Human Bone Morphogenetic Protein-2 soaked Absorbable Collagen Sponge implantation at surgical defect. Radiographs and clinical examinations were done upto 3 months to evaluate healing. Radiographic and clinical assessments revealed bone regeneration and restoration of the maxillary surgical defects in all 10 patients. No evidence of graft failure was noted. The Recombinant Human Bone Morphogenetic Protein-2 soaked Absorbable Collagen Sponge carrier is thus proved to be a viable option for the treatment of maxillary periapical surgical defects.

Keywords: Bone morphogenetic proteins; Panoramic radiography; Radicular cyst; Type I Collagen

References

  1. J Bone Joint Surg Am. 1997 Dec;79(12 ):1778-90 - PubMed
  2. Eur J Endocrinol. 2000 Jan;142(1):9-21 - PubMed
  3. J Periodontol. 2000 Aug;71(8):1241-57 - PubMed
  4. Science. 1965 Nov 12;150(3698):893-9 - PubMed
  5. BMC Med. 2011 May 31;9:66 - PubMed
  6. J Dent Res. 1971 Nov-Dec;50(6):1392-406 - PubMed
  7. J Oral Maxillofac Surg. 2000 Jul;58(7):761-6 - PubMed
  8. Dentomaxillofac Radiol. 2009 Oct;38(7):438-44 - PubMed
  9. Saudi Dent J. 2011 Jan;23(1):9-15 - PubMed
  10. Oral Maxillofac Surg Clin North Am. 2002 Feb;14(1):1-14 - PubMed
  11. Int J Periodontics Restorative Dent. 1997 Apr;17 (2):124-39 - PubMed
  12. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006 Jan;101(1):116-25 - PubMed
  13. Annu Rev Cell Biol. 1990;6:597-641 - PubMed
  14. Expert Opin Drug Saf. 2005 Jan;4(1):75-89 - PubMed
  15. Clin Orthop Relat Res. 2002 Feb;(395):110-20 - PubMed
  16. J Oral Maxillofac Surg. 2009 Sep;67(9):1947-60 - PubMed
  17. Int J Periodontics Restorative Dent. 1997 Feb;17(1):11-25 - PubMed
  18. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S128-35 - PubMed
  19. J Bone Joint Surg Am. 2001;83-A Suppl 1(Pt 2):S146-50 - PubMed

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