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Ootsuka Y, Tanaka M. Control of cutaneous blood flow by central nervous system. Temperature (Austin). 2015;2(3):392-405doi: 10.1080/23328940.2015.1069437.
Ootsuka, Y., & Tanaka, M. (2015). Control of cutaneous blood flow by central nervous system. Temperature (Austin, Tex.), 2(3), 392-405. https://doi.org/10.1080/23328940.2015.1069437
Ootsuka, Youichirou, and Tanaka, Mutsumi. "Control of cutaneous blood flow by central nervous system." Temperature (Austin, Tex.) vol. 2,3 (2015): 392-405. doi: https://doi.org/10.1080/23328940.2015.1069437
Ootsuka Y, Tanaka M. Control of cutaneous blood flow by central nervous system. Temperature (Austin). 2015 Jul 28;2(3):392-405. doi: 10.1080/23328940.2015.1069437. eCollection 2015. PMID: 27227053; PMCID: PMC4843916.
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Temperature (Austin). 2015 Jul 28;2(3):392-405. doi: 10.1080/23328940.2015.1069437. eCollection 2015.

Control of cutaneous blood flow by central nervous system.

Temperature (Austin, Tex.)

Youichirou Ootsuka, Mutsumi Tanaka

Affiliations

  1. Centre for Neuroscience; Department of Human Physiology; School of Medicine; Flinders University; Bedford Park; South Australia, Australia; Department of Physiology; Graduate School of Medical and Dental Sciences; Kagoshima University; Kagoshima, Japan.
  2. Health Effects Research Group; Energy and Environment Research Division; Japan Automobile Research Institute ; Tsukuba, Ibaraki, Japan.

PMID: 27227053 PMCID: PMC4843916 DOI: 10.1080/23328940.2015.1069437

Abstract

Hairless skin acts as a heat exchanger between body and environment, and thus greatly contributes to body temperature regulation by changing blood flow to the skin (cutaneous) vascular bed during physiological responses such as cold- or warm-defense and fever. Cutaneous blood flow is also affected by alerting state; we 'go pale with fright'. The rabbit ear pinna and the rat tail have hairless skin, and thus provide animal models for investigating central pathway regulating blood flow to cutaneous vascular beds. Cutaneous blood flow is controlled by the centrally regulated sympathetic nervous system. Sympathetic premotor neurons in the medullary raphé in the lower brain stem are labeled at early stage after injection of trans-synaptic viral tracer into skin wall of the rat tail. Inactivation of these neurons abolishes cutaneous vasomotor changes evoked as part of thermoregulatory, febrile or psychological responses, indicating that the medullary raphé is a common final pathway to cutaneous sympathetic outflow, receiving neural inputs from upstream nuclei such as the preoptic area, hypothalamic nuclei and the midbrain. Summarizing evidences from rats and rabbits studies in the last 2 decades, we will review our current understanding of the central pathways mediating cutaneous vasomotor control.

Keywords: cutaneous vasoconstriction; medullary raphé; preoptic area; psychological hyperthermia; sympathetic nervous system

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