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Azboy İ, Özkaya M, Demir T, et al. Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone. SICOT J. 2016;2:24doi: 10.1051/sicotj/2016016.
Azboy, �. �., Özkaya, M., Demir, T., Demirtaş, A., Kağan Arslan, A., Özkul, E., Akcan, A., & Tolunay, T. (2016). Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone. SICOT-J, 224. https://doi.org/10.1051/sicotj/2016016
Azboy, İbrahim, et al. "Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone." SICOT-J vol. 2 (2016): 24. doi: https://doi.org/10.1051/sicotj/2016016
Azboy İ, Özkaya M, Demir T, Demirtaş A, Kağan Arslan A, Özkul E, Akcan A, Tolunay T. Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone. SICOT J. 2016;2:24. doi: 10.1051/sicotj/2016016. Epub 2016 May 16. PMID: 27194109; PMCID: PMC4868918.
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SICOT J. 2016;2:24. doi: 10.1051/sicotj/2016016. Epub 2016 May 16.

Biomechanical properties of osteoporotic rat femurs after different hormonal treatments: genistein, estradiol, and estradiol/progesterone.

SICOT-J

İbrahim Azboy, Mustafa Özkaya, Teyfik Demir, Abdullah Demirtaş, Arslan Kağan Arslan, Emin Özkul, Adnan Akcan, Tolga Tolunay

Affiliations

  1. Department of Orthopaedics and Traumatology, Dicle University, 2100 Diyarbak?r, Turkey.
  2. Department of Mechanical Engineering, TOBB University of Economics and Technology, 06560 Ankara, Turkey.
  3. Department of Orthopaedics, Göztepe Training and Research Hospital, 34888 ?stanbul, Turkey.
  4. Department of Orthopaedics and Traumatology, Yenimahalle Training and Research Hospital, 0637 Ankara, Turkey.

PMID: 27194109 PMCID: PMC4868918 DOI: 10.1051/sicotj/2016016

Abstract

INTRODUCTION: The purpose of the study is to compare the effects of genistein, estradiol, estradiol/progesterone combination on the bone mineral density and biomechanical properties of ovariectomized rats' bone.

METHODS: 50 female adult Sprague-Dawley rats were divided into five groups. Bilaterally ovaeriectomy were performed in all groups except the sham-operated group. Groups were a sham-operated group and a control group (water was given), estradiol treated group (17-β estradiol 0.015 mg/kg per day), genistein treated group (genistein 10 mg/kg per day), and an estradiol/progesterone combination group (17-β estradiol 0.015 mg/kg plus drosperinone 0.028 mg/kg per day). The water or hormones were implemented in relevant groups for eight weeks by orogasthric catheter. The bone mineral density and biomechanical properties of the femur were analyzed.

RESULTS: Genistein, estradiol, and estradiol/progesterone groups increased bone mineral density significantly compared to the control group. In diaphysis and metaphysis bending test, all groups had higher peak load values than the control group. There were statistically significant differences between the estrogen/progesterone group and control group in diaphysis bending with regard to peak load. There were statistically significant differences between the estradiol and control groups in metaphysis bending with regard to peak load. In axial rotation test, all groups had higher peak torque values than the control groups.

CONCLUSIONS: Genistein, estradiol and estrogen/progesterone combination improved the biomechanical properties of the ovariectomized rat bone. Genistein which has less side effects may be considered as an alternative in the treatment of postmenopausal osteoporosis.

© The Authors, published by EDP Sciences, 2016.

References

  1. Osteoporos Int. 2000;11(8):721-4 - PubMed
  2. J Bone Miner Res. 2007 Nov;22(11):1791-7 - PubMed
  3. Climacteric. 2002 Jun;5(2):190-6 - PubMed
  4. BMJ. 1989 Jan 21;298(6667):147-51 - PubMed
  5. J Nutr Sci Vitaminol (Tokyo). 1998 Apr;44(2):257-68 - PubMed
  6. Endocrinology. 1998 Oct;139(10):4252-63 - PubMed
  7. Int J Mol Sci. 2012;13(1):56-70 - PubMed
  8. Ulus Travma Acil Cerrahi Derg. 2010 Jan;16(1):95-7 - PubMed
  9. Maturitas. 2007 May 20;57(1):81-4 - PubMed
  10. J Natl Cancer Inst. 1999 Jul 7;91(13):1131-7 - PubMed
  11. Public Health Nutr. 1999 Dec;2(4):489-504 - PubMed
  12. Phytomedicine. 2010 May;17(6):424-30 - PubMed
  13. Steroids. 2000 Oct-Nov;65(10-11):659-64 - PubMed
  14. Lancet. 1976 May 15;1(7968):1038-41 - PubMed
  15. J Orthop Surg Res. 2008 Mar 02;3:12 - PubMed
  16. Bone. 2001 Mar;28(3):327-31 - PubMed
  17. J Natl Cancer Inst. 1997 Aug 6;89(15):1110-6 - PubMed
  18. Br J Pharmacol. 2008 Nov;155(6):896-905 - PubMed
  19. J Bone Miner Res. 2002 Oct;17 (10 ):1904-12 - PubMed
  20. J Nutr. 1996 Jan;126(1):161-7 - PubMed
  21. Obstet Gynecol. 1995 Feb;85(2):304-13 - PubMed
  22. Ann Intern Med. 2007 Jun 19;146(12):839-47 - PubMed

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