Display options
Cite
Weon JB, Jung YS, Ma CJ. Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice. Biomol Ther (Seoul). 2016;24(3):298-304doi: 10.4062/biomolther.2015.083.
Weon, J. B., Jung, Y. S., & Ma, C. J. (2016). Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice. Biomolecules & therapeutics, 24(3), 298-304. https://doi.org/10.4062/biomolther.2015.083
Weon, Jin Bae, et al. "Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice." Biomolecules & therapeutics vol. 24,3 (2016): 298-304. doi: https://doi.org/10.4062/biomolther.2015.083
Weon JB, Jung YS, Ma CJ. Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice. Biomol Ther (Seoul). 2016 May 01;24(3):298-304. doi: 10.4062/biomolther.2015.083. PMID: 27133261; PMCID: PMC4859793.
Copy Download .nbib Format: NLM
Share it on

Biomol Ther (Seoul). 2016 May 01;24(3):298-304. doi: 10.4062/biomolther.2015.083.

Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice.

Biomolecules & therapeutics

Jin Bae Weon, Youn Sik Jung, Choong Je Ma

Affiliations

  1. Department of Medical Biomaterials Engineering, College of Biomedical Science, Kangwon National University, Chuncheon 24341, Republic of Korea.
  2. Institute of Bioscience and Biotechnology, Kangwon National University, Chuncheon 24341, Republic of Korea.

PMID: 27133261 PMCID: PMC4859793 DOI: 10.4062/biomolther.2015.083

Abstract

Dianthus superbus (D. superbus) is a traditional crude drug used for the treatment of urethritis, carbuncles and carcinomas. The objective of this study was to confirm the cognitive enhancing effect of D. superbus in memory impairment induced mice and to elucidate the possible potential mechanism. Effect of D. superbus on scopolamine induced memory impairment on mice was evaluated using the Morris water maze and passive avoidance tests. We also investigated acetylcholinesterase (AChE) activity and brain-derived neurotropic factor (BDNF) expression in scopolamine-induced mice. HPLC-DAD analysis was performed to identify active compounds in D. superbus. The results revealed that D. superbus attenuated the learning and memory impairment induced by scopolamine. D. superbus also inhibited AChE levels in the hippocampi of the scopolamine-injected mice. Moreover, D. superbus increased BDNF expression in the hippocampus. Eight compounds were identified using HPLC-DAD analysis. The content of 4-hydroxyphenyl acetic acid was higher than contents of other compounds. These results indicated that D. superbus improved memory functioning accompanied by inhibition of AChE and upregulation of BDNF, suggesting that D. superbus may be a useful therapeutic agent for the prevention or treatment of Alzheimer's disease.

Keywords: Acetylcholinesterase; Brain-derived neurotropic factor; Cognitive enhancing effect; Dianthus superbus

References

  1. Chem Pharm Bull (Tokyo). 2005 Mar;53(3):336-8 - PubMed
  2. Science. 1983 Mar 11;219(4589):1184-90 - PubMed
  3. Prog Neurobiol. 2005 Jun;76(2):99-125 - PubMed
  4. J Nat Prod. 2004 Sep;67(9):1522-7 - PubMed
  5. J Asian Nat Prod Res. 2010 Jun;12(6):458-63 - PubMed
  6. Brain Res Brain Res Rev. 1995 Nov;21(3):285-300 - PubMed
  7. Br J Clin Pharmacol. 1999 Oct;48(4):471-80 - PubMed
  8. J Physiol. 1967 Jul;191(1):215-24 - PubMed
  9. J Neurosci Methods. 1984 May;11(1):47-60 - PubMed
  10. Chin Med. 2011 Sep 30;6:35 - PubMed
  11. J Inflamm (Lond). 2012 Oct 30;9(1):41 - PubMed
  12. Chem Pharm Bull (Tokyo). 2011;59(4):518-21 - PubMed
  13. Am J Transplant. 2013 May;13(5):1159-67 - PubMed
  14. Neuroscientist. 2008 Apr;14(2):147-56 - PubMed
  15. Eur Neurol. 2002;47(1):64-70 - PubMed
  16. Bioorg Med Chem Lett. 2012 Mar 1;22(5):1908-11 - PubMed
  17. Neuropharmacology. 2014 Jan;76 Pt C:664-76 - PubMed
  18. Neuroscience. 1986 Sep;19(1):1-28 - PubMed
  19. Can Psychiatr Assoc J. 1978 Jan;23(4):229-33 - PubMed
  20. Nat Prod Res. 2013;27(18):1691-4 - PubMed
  21. Cancer Epidemiol. 2012 Feb;36(1):e40-5 - PubMed
  22. Behav Neural Biol. 1986 Mar;45(2):169-84 - PubMed

Publication Types