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Gauvin DV, Yoder JD, Tapp RL, et al. Small Compartment Toxicity: CN VIII and Quality of Life: Hearing Loss, Tinnitus, and Balance Disorders. Int J Toxicol. 2016;36(1):8-20doi: 10.1177/1091581816648905.
Gauvin, D. V., Yoder, J. D., Tapp, R. L., & Baird, T. J. (2017). Small Compartment Toxicity: CN VIII and Quality of Life: Hearing Loss, Tinnitus, and Balance Disorders. International journal of toxicology, 36(1), 8-20. https://doi.org/10.1177/1091581816648905
Gauvin, David V, et al. "Small Compartment Toxicity: CN VIII and Quality of Life: Hearing Loss, Tinnitus, and Balance Disorders." International journal of toxicology vol. 36,1 (2017): 8-20. doi: https://doi.org/10.1177/1091581816648905
Gauvin DV, Yoder JD, Tapp RL, Baird TJ. Small Compartment Toxicity: CN VIII and Quality of Life: Hearing Loss, Tinnitus, and Balance Disorders. Int J Toxicol. 2017 Jan 01;36(1):8-20. doi: 10.1177/1091581816648905. Epub 2016 May 18. PMID: 27194512.
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Int J Toxicol. 2017 Jan 01;36(1):8-20. doi: 10.1177/1091581816648905. Epub 2016 May 18.

Small Compartment Toxicity: CN VIII and Quality of Life: Hearing Loss, Tinnitus, and Balance Disorders.

International journal of toxicology

David V Gauvin, Joshua D Yoder, Rachel L Tapp, Theodore J Baird

Affiliations

  1. Neurobehavioral Sciences, MPI Research Inc, Mattawan, MI, USA [email protected].
  2. Neurobehavioral Sciences, MPI Research Inc, Mattawan, MI, USA.
  3. Drug Safety Assessment, MPI Research Inc, Mattawan, MI, USA.

PMID: 27194512 DOI: 10.1177/1091581816648905

Abstract

Life experiences, industrial/environmental exposures, and administration of Food and Drug Administration (FDA)-approved drugs may have unintended but detrimental effects on peripheral and central auditory pathways. Most relevant to the readership of this journal is the role that drug treatments approved by the FDA as safe and effective appear to interact with 3 independent modes of toxicity within the small compartment of the ear. What may seem to be trivial drug-induced toxicity has the potential to change important measures of quality of life and functional capacity of mid- to late-life patients. Drugs meant to treat can become the source of interference in the activities of daily living, and as a result, treatment compliance may be jeopardized. Ototoxicity has been defined as the tendency of certain therapeutic agents and other chemical substances to cause functional impairments and cellular degeneration of the tissues of the inner ear resulting in hearing loss. However, one of the largest contributors to hospitalizations is fall-related injuries in the elderly patients associated with disorders of vestibular function linked to progressive and drug-induced toxicities. Tinnitus affects 35 to 50 million adults representing approximately 25% of the US population, with 12 million seeking medical care and 2 to 3 million reporting symptoms that were severely debilitating. This review is intended to highlight these targets of neurotoxicity that threaten the usefulness of drug treatments deemed safe and effective prior to access by the general public.

© The Author(s) 2016.

Keywords: balance; drug-induced deafness; eighth cranial nerve; ototoxicity; quality of life; tinnitus; vestibular disorders

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