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Bolaman Z, Köseoğlu MH, Demir S, et al. α-Tokoferolün Sıçan Böbreğinde Sisplatinin Yol Açtığı Lipid Peroksidasyonuna Etkisi. Effect of α-Tocopherol on Lipid Peroxidation Caused by Cisplatin in Rat Kidney. Turk J Haematol. 2003;20(1):35-8
Bolaman, Z., Köseoğlu, M. H., Demir, S., Kadıköylü, G., Barutca, S., Atalay, H., & Aslan, D. (2003). α-Tokoferolün Sıçan Böbreğinde Sisplatinin Yol Açtığı Lipid Peroksidasyonuna Etkisi. Effect of α-Tocopherol on Lipid Peroxidation Caused by Cisplatin in Rat Kidney. Turkish journal of haematology : official journal of Turkish Society of Haematology, 20(1), 35-8.
Bolaman, Zahit, et al. "α-Tokoferolün Sıçan Böbreğinde Sisplatinin Yol Açtığı Lipid Peroksidasyonuna Etkisi." Effect of α-Tocopherol on Lipid Peroxidation Caused by Cisplatin in Rat Kidney. Turkish journal of haematology : official journal of Turkish Society of Haematology vol. 20,1 (2003): 35-8.
Bolaman Z, Köseoğlu MH, Demir S, Kadıköylü G, Barutca S, Atalay H, Aslan D. α-Tokoferolün Sıçan Böbreğinde Sisplatinin Yol Açtığı Lipid Peroksidasyonuna Etkisi. Effect of α-Tocopherol on Lipid Peroxidation Caused by Cisplatin in Rat Kidney. Turk J Haematol. 2003 Mar 05;20(1):35-8. PMID: 27265333.
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Turk J Haematol. 2003 Mar 05;20(1):35-8.

Effect of α-Tocopherol on Lipid Peroxidation Caused by Cisplatin in Rat Kidney.

Turkish journal of haematology : official journal of Turkish Society of Haematology

Zahit Bolaman, Mehmet H Köseoğlu, Süleyman Demir, Gürhan Kadıköylü, Sabri Barutca, Habip Atalay, Diler Aslan

PMID: 27265333

Abstract

Cisplatin (CDDP) is one of the most commonly used antineoplastic agents in current clinical practice. The major toxicities of CDDP are nonhaematological as nephrotoxicity and ototoxicity. Free oxygen radicals are known to play major role in CDDP-induced acute renal failure in rats. α-tocopherol is one of the well-known antioxidant agents. This study was designed to investigate the role of α-tocopherol pretreatment against CDDP-induced lipid peroxidation in rat kidney. Male Wistar rats were divided into three groups and treated as follows: control (saline intraperitoneally), CDDP (10 kg/kg, intraperitoneally), α-tocopherol (200 kg/kg, plus CDDP, intraperitoneally). Rats were sacrificed on third day of the treatment, and kidney tissues were obtained and analyzed. CDDP-treated rats showed high malondialdehyde (MDA) levels (p< 0.05). In the CDDP plus α-tocopherol group, renal MDA levels were not significantly different from the controls. These data suggest that α-tocopherol may be used to prevent CDDP-induced lipid peroxidation.

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