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Bonekey Rep. 2016 May 18;5:802. doi: 10.1038/bonekey.2016.29. eCollection 2016.

Osteoimmunology: from mice to humans.

BoneKEy reports

Patrizia D'Amelio, Francesca Sassi

Affiliations

  1. Department of Medical Science-Section of Gerontology-University of Torino , Torino, Italy.

PMID: 27195109 PMCID: PMC4870940 DOI: 10.1038/bonekey.2016.29

Abstract

The immune system has been recognized as one of the most important regulators of bone turnover and its deregulation is implicated in several bone diseases such as postmenopausal osteoporosis and inflammatory bone loss; recently it has been suggested that the gut microbiota may influence bone turnover by modulation of the immune system. The study of the relationship between the immune system and bone metabolism is generally indicated under the term 'osteoimmunology'. The vast majority of these studies have been performed in animal models; however, several data have been confirmed in humans as well: this review summarizes recent data on the relationship between the immune system and bone with particular regard to the data confirmed in humans.

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