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Podzimska-Sroka D, O'Shea C, Gregersen PL, et al. NAC Transcription Factors in Senescence: From Molecular Structure to Function in Crops. Plants (Basel). 2015;4(3):412-48doi: 10.3390/plants4030412.
Podzimska-Sroka, D., O'Shea, C., Gregersen, P. L., & Skriver, K. (2015). NAC Transcription Factors in Senescence: From Molecular Structure to Function in Crops. Plants (Basel, Switzerland), 4(3), 412-48. https://doi.org/10.3390/plants4030412
Podzimska-Sroka, Dagmara, et al. "NAC Transcription Factors in Senescence: From Molecular Structure to Function in Crops." Plants (Basel, Switzerland) vol. 4,3 (2015): 412-48. doi: https://doi.org/10.3390/plants4030412
Podzimska-Sroka D, O'Shea C, Gregersen PL, Skriver K. NAC Transcription Factors in Senescence: From Molecular Structure to Function in Crops. Plants (Basel). 2015 Jul 13;4(3):412-48. doi: 10.3390/plants4030412. PMID: 27135336; PMCID: PMC4844398.
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Plants (Basel). 2015 Jul 13;4(3):412-48. doi: 10.3390/plants4030412.

NAC Transcription Factors in Senescence: From Molecular Structure to Function in Crops.

Plants (Basel, Switzerland)

Dagmara Podzimska-Sroka, Charlotte O'Shea, Per L Gregersen, Karen Skriver

Affiliations

  1. Department of Genetics and Biotechnology, Aarhus University, Forsøgsvej 1, Slagelse DK-4200, Denmark. [email protected].
  2. Department of Biology, University of Copenhagen, 5 Ole Maaloesvej, Copenhagen DK-2200, Denmark. [email protected].
  3. Department of Genetics and Biotechnology, Aarhus University, Forsøgsvej 1, Slagelse DK-4200, Denmark. [email protected].
  4. Department of Biology, University of Copenhagen, 5 Ole Maaloesvej, Copenhagen DK-2200, Denmark. [email protected].

PMID: 27135336 PMCID: PMC4844398 DOI: 10.3390/plants4030412

Abstract

Within the last decade, NAC transcription factors have been shown to play essential roles in senescence, which is the focus of this review. Transcriptome analyses associate approximately one third of Arabidopsis NAC genes and many crop NAC genes with senescence, thereby implicating NAC genes as important regulators of the senescence process. The consensus DNA binding site of the NAC domain is used to predict NAC target genes, and protein interaction sites can be predicted for the intrinsically disordered transcription regulatory domains of NAC proteins. The molecular characteristics of these domains determine the interactions in gene regulatory networks. Emerging local NAC-centered gene regulatory networks reveal complex molecular mechanisms of stress- and hormone-regulated senescence and basic physiological steps of the senescence process. For example, through molecular interactions involving the hormone abscisic acid, Arabidopsis NAP promotes chlorophyll degradation, a hallmark of senescence. Furthermore, studies of the functional rice ortholog, OsNAP, suggest that NAC genes can be targeted to obtain specific changes in lifespan control and nutrient remobilization in crop plants. This is also exemplified by the wheat NAM1 genes which promote senescence and increase grain zinc, iron, and protein content. Thus, NAC genes are promising targets for fine-tuning senescence for increased yield and quality.

Keywords: NAC transcription factor; abiotic stress; crop breeding; domain structure; gene regulatory network; senescence

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