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Lubas M, Chlebowski A, Dziembowski A, et al. Biochemistry and Function of RNA Exosomes. Enzymes. 2012;31:1-30doi: 10.1016/B978-0-12-404740-2.00001-X.
Lubas, M., Chlebowski, A., Dziembowski, A., & Jensen, T. H. (2012). Biochemistry and Function of RNA Exosomes. The Enzymes, 311-30. https://doi.org/10.1016/B978-0-12-404740-2.00001-X
Lubas, Michal, et al. "Biochemistry and Function of RNA Exosomes." The Enzymes vol. 31 (2012): 1-30. doi: https://doi.org/10.1016/B978-0-12-404740-2.00001-X
Lubas M, Chlebowski A, Dziembowski A, Jensen TH. Biochemistry and Function of RNA Exosomes. Enzymes. 2012;31:1-30. doi: 10.1016/B978-0-12-404740-2.00001-X. Epub 2012 Sep 29. PMID: 27166438.
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Enzymes. 2012;31:1-30. doi: 10.1016/B978-0-12-404740-2.00001-X. Epub 2012 Sep 29.

Biochemistry and Function of RNA Exosomes.

The Enzymes

Michal Lubas, Aleksander Chlebowski, Andrzej Dziembowski, Torben Heick Jensen

Affiliations

  1. Department of Molecular Biology and Genetics, Centre for mRNP Biogenesis and Metabolism, Aarhus University, C.F. Møllers Allé 3, Aarhus C, Denmark; Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawi?skiego 5a, Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawi?skiego 5a, Warsaw, Poland.
  2. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawi?skiego 5a, Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawi?skiego 5a, Warsaw, Poland.
  3. Institute of Biochemistry and Biophysics, Polish Academy of Sciences, ul. Pawi?skiego 5a, Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, University of Warsaw, ul. Pawi?skiego 5a, Warsaw, Poland. Electronic address: [email protected].
  4. Department of Molecular Biology and Genetics, Centre for mRNP Biogenesis and Metabolism, Aarhus University, C.F. Møllers Allé 3, Aarhus C, Denmark. Electronic address: [email protected].

PMID: 27166438 DOI: 10.1016/B978-0-12-404740-2.00001-X

Abstract

Discovery of the evolutionary conserved RNA exosome was a milestone in RNA biology. First identified as an activity essential for the processing of ribosomal RNA, the exosome has since proved to be central for RNA processing and degradation in both the nucleus and the cytoplasm of eukaryotic cells. This multisubunit protein complex consists of a catalytically inert 9-subunit core endowed with associated ribonucleolytic activities and further assisted by compartment-specific cofactors required for its activation and substrate targeting. Although many features of exosome biology are known, fundamental aspects are still under investigation. In this chapter, we review current biochemical and functional knowledge of eukaryotic exosomes. After introducing some of their nuclear and cytoplasmic functions, we discuss the structural organization and evolutionary aspects of exosome complexes. Finally, we describe catalytic properties of the complex and its regulation by cofactors.

Copyright © 2012 Elsevier Inc. All rights reserved.

Keywords: Exosome; RNA degradation; RNA processing; Ribonuclease

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