Display options
Cite
Roy K, Chanfreau GF. The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism. Enzymes. 2012;31:213-35doi: 10.1016/B978-0-12-404740-2.00010-0.
Roy, K., & Chanfreau, G. F. (2012). The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism. The Enzymes, 31213-35. https://doi.org/10.1016/B978-0-12-404740-2.00010-0
Roy, Kevin, and Chanfreau, Guillaume F. "The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism." The Enzymes vol. 31 (2012): 213-35. doi: https://doi.org/10.1016/B978-0-12-404740-2.00010-0
Roy K, Chanfreau GF. The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism. Enzymes. 2012;31:213-35. doi: 10.1016/B978-0-12-404740-2.00010-0. Epub 2012 Sep 29. PMID: 27166447.
Copy Download .nbib Format: NLM
Share it on

Enzymes. 2012;31:213-35. doi: 10.1016/B978-0-12-404740-2.00010-0. Epub 2012 Sep 29.

The Diverse Functions of Fungal RNase III Enzymes in RNA Metabolism.

The Enzymes

Kevin Roy, Guillaume F Chanfreau

Affiliations

  1. Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California, USA.
  2. Department of Chemistry and Biochemistry and the Molecular Biology Institute, University of California, Los Angeles, California, USA. Electronic address: [email protected].

PMID: 27166447 DOI: 10.1016/B978-0-12-404740-2.00010-0

Abstract

Enzymes from the ribonuclease III family bind and cleave double-stranded RNA to initiate RNA processing and degradation of a large number of transcripts in bacteria and eukaryotes. This chapter focuses on the description of the diverse functions of fungal RNase III members in the processing and degradation of cellular RNAs, with a particular emphasis on the well-characterized representative in Saccharomyces cerevisiae, Rnt1p. RNase III enzymes fulfill important functions in the processing of the precursors of various stable noncoding RNAs such as ribosomal RNAs and small nuclear and nucleolar RNAs. In addition, they cleave and promote the degradation of specific mRNAs or improperly processed forms of certain mRNAs. The cleavage of these mRNAs serves both surveillance and regulatory functions. Finally, recent advances have shown that RNase III enzymes are involved in mediating fail-safe transcription termination by RNA polymerase II (Pol II), by cleaving intergenic stem-loop structures present downstream from Pol II transcription units. Many of these processing functions appear to be conserved in fungal species close to the Saccharomyces genus, and even in more distant eukaryotic species.

Copyright © 2012 Elsevier Inc. All rights reserved.

Keywords: Fungi; RNA degradation; RNA processing; RNase III; Rnt1p; Yeast

Publication Types