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Israr F, Mahmood ZA, Hassan F, et al. Pharmaceutical Evaluation of Cefuroxime Axetil Tablets Available in Drug Market of Pakistan. Indian J Pharm Sci. 2016;78(1):17-26doi: 10.4103/0250-474x.180242.
Israr, F., Mahmood, Z. A., Hassan, F., & Hasan, S. M. (2016). Pharmaceutical Evaluation of Cefuroxime Axetil Tablets Available in Drug Market of Pakistan. Indian journal of pharmaceutical sciences, 78(1), 17-26. https://doi.org/10.4103/0250-474x.180242
Israr, F, et al. "Pharmaceutical Evaluation of Cefuroxime Axetil Tablets Available in Drug Market of Pakistan." Indian journal of pharmaceutical sciences vol. 78,1 (2016): 17-26. doi: https://doi.org/10.4103/0250-474x.180242
Israr F, Mahmood ZA, Hassan F, Hasan SM. Pharmaceutical Evaluation of Cefuroxime Axetil Tablets Available in Drug Market of Pakistan. Indian J Pharm Sci. 2016 Jan-Feb;78(1):17-26. doi: 10.4103/0250-474x.180242. PMID: 27168677; PMCID: PMC4852570.
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Indian J Pharm Sci. 2016 Jan-Feb;78(1):17-26. doi: 10.4103/0250-474x.180242.

Pharmaceutical Evaluation of Cefuroxime Axetil Tablets Available in Drug Market of Pakistan.

Indian journal of pharmaceutical sciences

F Israr, Z A Mahmood, F Hassan, S M F Hasan

Affiliations

  1. Department of Pharmaceutics, Faculty of Pharmacy, University of Karachi, University Road, Karachi 75270, Pakistan.

PMID: 27168677 PMCID: PMC4852570 DOI: 10.4103/0250-474x.180242

Abstract

Cefuroxime is a second generation cephalosporin antibiotic with a broad spectrum activity against Gram positive and Gram negative bacteria. The purpose of this research work was to evaluate the pharmaceutical quality standards of four different brands of cefuroxime axetil 125 mg tablets with different price ranges purchased from retail pharmacies of Pakistan. The brands were tested for physicochemical evaluation and in vitro dissolution studies in different medium like 0.07N HCl, distilled water, 0.1N HCl of pH 1.2 and phosphate buffers of pH 4.5 and pH 6.8. Statistical analysis, model dependent (zero order, first order, Korsmeyer-Peppas, Hixson-Crowell, Weibull) and model independent (Difference f1, similarity f2) approaches were applied to multiple dissolution profile of all brands. All brands were found to be similar with reference and meeting the compendial quality standard. Inter brand variation was observed in disintegration time and assay which was resulted in significant differences (P<0.05) in drug release data and Weibull was observed as best fill model.

Keywords: Cefuroxime axetil; different brands; dissolution studies; model dependent and independent approaches; statistical analysis

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