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Eisenmann ED, Rorabaugh BR, Zoladz PR. Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents. Front Psychiatry. 2016;7:71doi: 10.3389/fpsyt.2016.00071.
Eisenmann, E. D., Rorabaugh, B. R., & Zoladz, P. R. (2016). Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents. Frontiers in psychiatry, 771. https://doi.org/10.3389/fpsyt.2016.00071
Eisenmann, Eric D, et al. "Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents." Frontiers in psychiatry vol. 7 (2016): 71. doi: https://doi.org/10.3389/fpsyt.2016.00071
Eisenmann ED, Rorabaugh BR, Zoladz PR. Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents. Front Psychiatry. 2016 Apr 25;7:71. doi: 10.3389/fpsyt.2016.00071. eCollection 2016. PMID: 27199778; PMCID: PMC4843048.
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Front Psychiatry. 2016 Apr 25;7:71. doi: 10.3389/fpsyt.2016.00071. eCollection 2016.

Acute Stress Decreases but Chronic Stress Increases Myocardial Sensitivity to Ischemic Injury in Rodents.

Frontiers in psychiatry

Eric D Eisenmann, Boyd R Rorabaugh, Phillip R Zoladz

Affiliations

  1. Department of Psychology, Sociology and Criminal Justice, Ohio Northern University , Ada, OH , USA.
  2. Department of Pharmaceutical and Biomedical Sciences, Ohio Northern University , Ada, OH , USA.

PMID: 27199778 PMCID: PMC4843048 DOI: 10.3389/fpsyt.2016.00071

Abstract

Cardiovascular disease (CVD) is the largest cause of mortality worldwide, and stress is a significant contributor to the development of CVD. The relationship between acute and chronic stress and CVD is well evidenced. Acute stress can lead to arrhythmias and ischemic injury. However, recent evidence in rodent models suggests that acute stress can decrease sensitivity to myocardial ischemia-reperfusion injury (IRI). Conversely, chronic stress is arrhythmogenic and increases sensitivity to myocardial IRI. Few studies have examined the impact of validated animal models of stress-related psychological disorders on the ischemic heart. This review examines the work that has been completed using rat models to study the effects of stress on myocardial sensitivity to ischemic injury. Utilization of animal models of stress-related psychological disorders is critical in the prevention and treatment of cardiovascular disorders in patients experiencing stress-related psychiatric conditions.

Keywords: PTSD; anxiety; cardiovascular; ischemia; rodent; stress

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