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Wang L, Cang J, Xue Z. Protective effects of thoracic epidural anesthesia on hypoxia-induced acute lung injury in rabbits. Exp Ther Med. 2016;11(5):2021-2027doi: 10.3892/etm.2016.3151.
Wang, L., Cang, J., & Xue, Z. (2016). Protective effects of thoracic epidural anesthesia on hypoxia-induced acute lung injury in rabbits. Experimental and therapeutic medicine, 11(5), 2021-2027. https://doi.org/10.3892/etm.2016.3151
Wang, Lijun, et al. "Protective effects of thoracic epidural anesthesia on hypoxia-induced acute lung injury in rabbits." Experimental and therapeutic medicine vol. 11,5 (2016): 2021-2027. doi: https://doi.org/10.3892/etm.2016.3151
Wang L, Cang J, Xue Z. Protective effects of thoracic epidural anesthesia on hypoxia-induced acute lung injury in rabbits. Exp Ther Med. 2016 May;11(5):2021-2027. doi: 10.3892/etm.2016.3151. Epub 2016 Mar 11. PMID: 27168845; PMCID: PMC4840638.
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Exp Ther Med. 2016 May;11(5):2021-2027. doi: 10.3892/etm.2016.3151. Epub 2016 Mar 11.

Protective effects of thoracic epidural anesthesia on hypoxia-induced acute lung injury in rabbits.

Experimental and therapeutic medicine

Lijun Wang, Jing Cang, Zhanggang Xue

Affiliations

  1. Department of Anesthesiology, Ear, Eye, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China.
  2. Department of Anesthesiology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China.

PMID: 27168845 PMCID: PMC4840638 DOI: 10.3892/etm.2016.3151

Abstract

The mechanism underlying the effect of thoracic epidural anesthesia (TEA) on hypoxia-induced acute lung injury (ALI) is currently unknown. In the present study, a rabbit acute lung injury model was established to investigate the effects of TEA on inflammatory factors, pulmonary surfactant and ultrastructure. A total of 56 rabbits were randomly assigned to four groups (n=14 per group): Control group (Group C), hypoxia group (Group H), sevoflurane group (Group S) and combined sevoflurane-epidural anesthesia group (Group ES). The ALI model was considered to have been successfully induced when the ratio of arterial oxygen partial pressure to fractional inspired oxygen was <300. The correct placement of a catheter for TEA was confirmed using epidurography. ALI was maintained for 3 h. Arterial blood samples were collected from all groups during spontaneous breathing (T

Keywords: anesthesia; epidural; inflammation; pulmonary surfactants; rabbit; respiratory distress syndrome

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