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Louis AG, Agrawal S, Gupta S. Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency. Am J Clin Exp Immunol. 2016;5(1):21-32
Louis, A. G., Agrawal, S., & Gupta, S. (2016). Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency. American journal of clinical and experimental immunology, 5(1), 21-32.
Louis, Ankmalika Gupta, et al. "Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency." American journal of clinical and experimental immunology vol. 5,1 (2016): 21-32.
Louis AG, Agrawal S, Gupta S. Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency. Am J Clin Exp Immunol. 2016 Mar 23;5(1):21-32. eCollection 2016. PMID: 27168952; PMCID: PMC4858603.
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Am J Clin Exp Immunol. 2016 Mar 23;5(1):21-32. eCollection 2016.

Analysis of subsets of B cells, Breg, CD4Treg and CD8Treg cells in adult patients with primary selective IgM deficiency.

American journal of clinical and experimental immunology

Ankmalika Gupta Louis, Sudhanshu Agrawal, Sudhir Gupta

Affiliations

  1. Program in Primary Immunodeficiency and Human Aging, Division of Basic and Clinical Immunology, University of California Irvine, California, USA.

PMID: 27168952 PMCID: PMC4858603

Abstract

Primary selective IgM deficiency (SIGMD) is a rare and recently IUIS-recognized primary immunodeficiency disease with increased susceptibility to infections, allergy, and autoimmune diseases. The pathogenesis of selective IgM remains unclear. The objective of the study was to understand the pathogenesis of selective IgM deficiency via a comprehensive analysis of subsets of B cells, naïve and memory subsets of CD4+ and CD8+ T cells, and Breg, CD4Treg, and CD8Treg cells. Twenty adult patients with SIGMD (serum IgM 4 mg/dl-32 mg/dl) and age-and gender-matched healthy controls were studied. Naïve B cells, transitional B cells, marginal zone B cells, germinal center B cells, IgM memory B cells, switched memory B cells, plasmablasts, CD21(low) B cells, B1 cells, CXCR3+ naive and memory B cells; naïve, central memory, and effector memory subsets of CD4+ and CD8+ T cells, and CD4Treg, CD8Treg and Breg were phenotypically analyzed using multicolor flow cytometry. A significant increase in CD21(low), IgM memory B cells, Breg and CD8Treg, and a significant decreased in germinal center B cells, and CXCR3+ naïve and memory B cells were observed in SIGMD. These alterations in subsets of B cells, and Breg and CD8Treg cells may play a role in the pathogenesis of SIGMD.

Keywords: B1 cells; Breg; CD21lo; CD4Treg; CD8Treg; CXCR3+ B cells; germinal center B cells; marginal zone B cells; memory B cells; memory T cells; transitional B cells

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