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Gollapudi S, Gupta S. Reversal of oxidative stress-induced apoptosis in T and B lymphocytes by Coenzyme Q10 (CoQ10). Am J Clin Exp Immunol. 2016;5(2):41-7
Gollapudi, S., & Gupta, S. (2016). Reversal of oxidative stress-induced apoptosis in T and B lymphocytes by Coenzyme Q10 (CoQ10). American journal of clinical and experimental immunology, 5(2), 41-7.
Gollapudi, Sastry, and Gupta, Sudhir. "Reversal of oxidative stress-induced apoptosis in T and B lymphocytes by Coenzyme Q10 (CoQ10)." American journal of clinical and experimental immunology vol. 5,2 (2016): 41-7.
Gollapudi S, Gupta S. Reversal of oxidative stress-induced apoptosis in T and B lymphocytes by Coenzyme Q10 (CoQ10). Am J Clin Exp Immunol. 2016 Apr 27;5(2):41-7. eCollection 2016. PMID: 27168954; PMCID: PMC4858601.
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Am J Clin Exp Immunol. 2016 Apr 27;5(2):41-7. eCollection 2016.

Reversal of oxidative stress-induced apoptosis in T and B lymphocytes by Coenzyme Q10 (CoQ10).

American journal of clinical and experimental immunology

Sastry Gollapudi, Sudhir Gupta

Affiliations

  1. Division of Basic and Clinical Immunology, University of California Irvine, CA 92697, USA.

PMID: 27168954 PMCID: PMC4858601

Abstract

Coenzyme Q10, (CoQ10) an electron transporter and an antioxidant, protects a variety of cell types against oxidative stress and apoptosis. However, protective effect of CoQ10 on oxidative stress-induced apoptosis in lymphocytes has not been studied in detail. In this study, we investigated the effect of CoQ10 on oxidative stress-induced apoptosis in lymphocytes. An exposure of peripheral blood lymphocytes to oxidative stressors, rotenone or hydrogen peroxide, lead to apoptosis. Pre-treatment of lymphocytes with CoQ10 resulted in a significantly reduced level of oxidative stress-induced apoptosis, which was associated with decreased reactive oxygen species production, an inhibition of mitochondrial membrane depolarization, and inhibition of activation of caspase-9 and caspase-3. Furthermore, CoQ10 inhibited oxidative stress induced apoptosis in both CD4+ T, and CD8+ T, and CD19+ B cells. Our findings suggest that CoQ10 may provide new therapeutic strategies for preventing oxidative stress-induced cell death and dysfunction in lymphocytes and lymphocyte subsets.

Keywords: Coenzyme Q10; apoptosis; lymphocytes; oxidative stress

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