Display options
Cite
Mokhtari F, Faghihi G, Basiri A, et al. Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne. Adv Biomed Res. 2016;5:72doi: 10.4103/2277-9175.180641.
Mokhtari, F., Faghihi, G., Basiri, A., Farhadi, S., Nilforoushzadeh, M., & Behfar, S. (2016). Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne. Advanced biomedical research, 572. https://doi.org/10.4103/2277-9175.180641
Mokhtari, Fatemeh, et al. "Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne." Advanced biomedical research vol. 5 (2016): 72. doi: https://doi.org/10.4103/2277-9175.180641
Mokhtari F, Faghihi G, Basiri A, Farhadi S, Nilforoushzadeh M, Behfar S. Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne. Adv Biomed Res. 2016 Apr 19;5:72. doi: 10.4103/2277-9175.180641. eCollection 2016. PMID: 27169103; PMCID: PMC4854036.
Copy Download .nbib Format: NLM
Share it on

Adv Biomed Res. 2016 Apr 19;5:72. doi: 10.4103/2277-9175.180641. eCollection 2016.

Comparison effect of azithromycin gel 2% with clindamycin gel 1% in patients with acne.

Advanced biomedical research

Fatemeh Mokhtari, Gita Faghihi, Akram Basiri, Sadaf Farhadi, Mohammadali Nilforoushzadeh, Shadi Behfar

Affiliations

  1. Department of Dermatology, Skin Diseases and Leishmaniasis Research Center, Isfahan, Iran.
  2. Department of Dermatology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

PMID: 27169103 PMCID: PMC4854036 DOI: 10.4103/2277-9175.180641

Abstract

BACKGROUND: Acne vulgaris is the most common skin disease. Local and systemic antimicrobial drugs are used for its treatment. But increasing resistance of Propionibacterium acnes to antibiotics has been reported.

MATERIALS AND METHODS: In a double-blind clinical trial, 40 patients with mild to moderate acne vulgaris were recruited. one side of the face was treated with Clindamycin Gel 1% and the other side with Azithromycin Topical Gel 2% BID for 8 weeks and then they were assessed.

RESULTS: Average age was 21. 8 ± 7 years. 82.5% of them were female. Average number of papules, pustules and comedones was similarly reduced in both groups and, no significant difference was observed between the two groups (P > 0.05, repeated measurs ANOVA). The mean indexes of ASI and TLC also significantly decreased during treatment in both groups, no significant difference was observed between the two groups. (P > 0.05, repeated measurs ANOVA). Also, impact of both drugs on papules and pustules was 2-3 times greater than the effect on comedones. Average satisfaction score was not significant between the two groups (P = 0.6, repeated measurs ANOVA). finally, frequency distribution of complications was not significant between the two groups (P > 0.05, Fisher Exact test).

CONCLUSION: Azithromycin gel has medical impact at least similar to Clindamycin Gel in treatment of mild to moderate acne vulgaris, and it may be consider as suitable drug for resistant acne to conventional topical therapy.

Keywords: Acne vulgaris; administration topical drug; azithromycin; clindamycin; drug treatment

References

  1. Int J Dermatol. 2013 Apr;52(4):418-25 - PubMed
  2. J Eur Acad Dermatol Venereol. 2013 Dec;27(12):1546-51 - PubMed
  3. Am J Clin Dermatol. 2004;5(2):79-84 - PubMed
  4. J Am Acad Dermatol. 1991 Mar;24(3):495-500 - PubMed
  5. Drugs. 2013 Jun;73(8):779-87 - PubMed
  6. J Dermatolog Treat. 2008;19(4):210-5 - PubMed
  7. Int J Dermatol. 2010 Sep;49(9):1003-7 - PubMed
  8. J Dermatolog Treat. 2004 Sep;15(5):295-302 - PubMed
  9. J Dermatol. 2012 Sep;39(9):794-6 - PubMed
  10. Mymensingh Med J. 2013 Jan;22(1):42-8 - PubMed
  11. Skinmed. 2011 Mar-Apr;9(2):86-94 - PubMed
  12. Expert Opin Pharmacother. 2014 Feb;15(2):173-92 - PubMed
  13. J Drugs Dermatol. 2013 Jun 1;12(6):644-9 - PubMed
  14. Indian J Dermatol Venereol Leprol. 2009 May-Jun;75(3):323-6 - PubMed
  15. J Antimicrob Chemother. 1998 Mar;41 Suppl B:37-46 - PubMed

Publication Types