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Oliveira NP, Dutra CG, Frantz GN, et al. Embryos from in Vitro Maturation (IVM) Technique Can Be Successfully Vitrified Resulting in the Birth of a Healthy Child. JBRA Assist Reprod. 2015;19(4):263-5doi: 10.5935/1518-0557.20150050.
Oliveira, N. P., Dutra, C. G., Frantz, G. N., Basso, C. G., Fortis, M. F., & Frantz, N. (2015). Embryos from in Vitro Maturation (IVM) Technique Can Be Successfully Vitrified Resulting in the Birth of a Healthy Child. JBRA assisted reproduction, 19(4), 263-5. https://doi.org/10.5935/1518-0557.20150050
Oliveira, Norma P de, et al. "Embryos from in Vitro Maturation (IVM) Technique Can Be Successfully Vitrified Resulting in the Birth of a Healthy Child." JBRA assisted reproduction vol. 19,4 (2015): 263-5. doi: https://doi.org/10.5935/1518-0557.20150050
Oliveira NP, Dutra CG, Frantz GN, Basso CG, Fortis MF, Frantz N. Embryos from in Vitro Maturation (IVM) Technique Can Be Successfully Vitrified Resulting in the Birth of a Healthy Child. JBRA Assist Reprod. 2015 Nov 01;19(4):263-5. doi: 10.5935/1518-0557.20150050. PMID: 27203203.
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JBRA Assist Reprod. 2015 Nov 01;19(4):263-5. doi: 10.5935/1518-0557.20150050.

Embryos from in Vitro Maturation (IVM) Technique Can Be Successfully Vitrified Resulting in the Birth of a Healthy Child.

JBRA assisted reproduction

Norma P de Oliveira, Caroline G Dutra, Gerta N Frantz, Carla G Basso, Marcela F Fortis, Nilo Frantz

Affiliations

  1. Nilo Frantz Reproduction Center - Porto Alegre - RS - Brazil.

PMID: 27203203 DOI: 10.5935/1518-0557.20150050

Abstract

IVM can be an advantageous technique when applied to PCOS (Polycystic Ovarian Syndrome) patients. The oocytes are retrieved from antral follicles of non-stimulated ovaries, specially preventing hyperstimulation syndrome. Apart from its role as a reproductive treatment, IVM has emerged as a promising tool for emergency fertility preservation, since it can be performed flexibly in either follicular or luteal phase. A 34-year-old patient with PCOS, high body mass index and tubal factor was submitted twice to IVM treatment. Her husband has low count spermatozoa. The first IVM cycle was in 2009, she transferred 3 fresh embryos and got pregnant giving birth to a healthy boy weighing 3.3 kg. In 2013, the patient returned for another IVM cycle and the embryos had to be vitrified because she failed to develop an adequate endometrium for transfer. In the next cycle, the endometrium was prepared using estrogen and progesterone and the two best embryos were warmed up and transferred. She became pregnant and after 36 weeks gave birth to a healthy girl weighing 2.7 kg. She still has four embryos left to transfer. IVM may be an alternative technique to be considered when dealing with PCOS patients. Although clinical outcomes are currently inferior when compared with conventional hormone driven ART (Artificial Reproductive Techniques), it does apply in some cases while preventing hyperstimulation risks. Thus, embryos obtained by IVM can also be vitrified with successful outcomes.

Keywords: Embryos; IVM; In vitro maturation; Polycystic Ovarian Syndrome; Vitrification

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