Display options
Cite
Mu YP, Peng SY. Relation between bile acids and myocardial damage in obstructive jaundice. World J Gastroenterol. 1997;3(3):174-6doi: 10.3748/wjg.v3.i3.174.
Mu, Y. P., & Peng, S. Y. (1997). Relation between bile acids and myocardial damage in obstructive jaundice. World journal of gastroenterology, 3(3), 174-6. https://doi.org/10.3748/wjg.v3.i3.174
Mu, Y P, and Peng, S Y. "Relation between bile acids and myocardial damage in obstructive jaundice." World journal of gastroenterology vol. 3,3 (1997): 174-6. doi: https://doi.org/10.3748/wjg.v3.i3.174
Mu YP, Peng SY. Relation between bile acids and myocardial damage in obstructive jaundice. World J Gastroenterol. 1997 Sep 15;3(3):174-6. doi: 10.3748/wjg.v3.i3.174. PMID: 27239141; PMCID: PMC4842882.
Copy Download .nbib Format: NLM
Share it on

World J Gastroenterol. 1997 Sep 15;3(3):174-6. doi: 10.3748/wjg.v3.i3.174.

Relation between bile acids and myocardial damage in obstructive jaundice.

World journal of gastroenterology

Y P Mu, S Y Peng

Affiliations

  1. Yi-Ping Mu, Shu-You Peng, Department of Surgery, Second Affiliated Hospital, Zhejiang Medical University, Hangzhou 310009, Zhejiang Province, China.

PMID: 27239141 PMCID: PMC4842882 DOI: 10.3748/wjg.v3.i3.174

Abstract

AIM: To investigate the morphologic changes of the myocardium and its relationship to serum bile acids in obstructive jaundice.

METHODS: Part 1: 35 rats were randomly assigned to three groups: Group I (BDL1, n = 11), the common bile duct (CBD) was ligated and severed and mice were then sacrificed after one week. Group I (BDL2, n = 11), the CBD was ligated and severed and mice were then killed after two weeks. Group I (SO, n = 13), the CBD was isolated. Hearts were collected for morphologic studies and blood was taken to determine the total serum bile acids (TAB). Part 2: 13 rats received gastric intubation of 10% 4 mL/kg sodium cholate. Their serum TBA and the heart's morphologic changes were then examined.

RESULTS: One to two weeks after the CBD was ligated and severed, damage was evident in the mitochondria within the myocardium and the serum TBA was significantly increased. When rats were administered sodium cholate to make their peak blood concentration mimic the average blood concentration in BDL2, a similar degree of myocardial damage was observed.

CONCLUSION: An increase in endogenous bile acids is one causative factor of myocardial damage in obstructive jaundice.

Keywords: Bile acids and salts; Cholestasis; Jaundice; Mitochondria, heart; Myocardium/pathology

References

  1. Gastroenterology. 1992 May;102(5):1752-9 - PubMed
  2. Surgery. 1986 Jul;100(1):14-20 - PubMed
  3. J Surg Res. 1994 Aug;57(2):316-36 - PubMed
  4. Am J Physiol. 1993 May;264(5 Pt 1):G835-9 - PubMed

Publication Types