Display options
Cite
Geis AL, Housseau F. Procarcinogenic regulatory T cells in microbial-induced colon cancer. Oncoimmunology. 2015;5(4):e1118601doi: 10.1080/2162402X.2015.1118601.
Geis, A. L., & Housseau, F. (2016). Procarcinogenic regulatory T cells in microbial-induced colon cancer. Oncoimmunology, 5(4), e1118601. https://doi.org/10.1080/2162402X.2015.1118601
Geis, Abby L, and Housseau, Franck. "Procarcinogenic regulatory T cells in microbial-induced colon cancer." Oncoimmunology vol. 5,4 (2016): e1118601. doi: https://doi.org/10.1080/2162402X.2015.1118601
Geis AL, Housseau F. Procarcinogenic regulatory T cells in microbial-induced colon cancer. Oncoimmunology. 2015 Dec 21;5(4):e1118601. doi: 10.1080/2162402X.2015.1118601. eCollection 2016 Apr. PMID: 27141400; PMCID: PMC4839357.
Copy Download .nbib Format: NLM
Share it on

Oncoimmunology. 2015 Dec 21;5(4):e1118601. doi: 10.1080/2162402X.2015.1118601. eCollection 2016 Apr.

Procarcinogenic regulatory T cells in microbial-induced colon cancer.

Oncoimmunology

Abby L Geis, Franck Housseau

Affiliations

  1. Department of Oncology, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University , Baltimore, MD, USA.

PMID: 27141400 PMCID: PMC4839357 DOI: 10.1080/2162402X.2015.1118601

Abstract

Regulatory T cell (Treg) promote IL-17-mediated colon tumorigenesis in multiple intestinal neoplasia (Min) mice colonized with enterotoxigenic Bacteroides fragilis (ETBF). Although they retain their immunosuppressive function, mucosal Treg are instrumental to initiate ETBF-triggered IL-17 colitis by limiting the availability of IL-2 in the local microenvironment. However, the mechanisms that trigger the recruitment of the pro-carcinogenic Treg in ETBF-colonized colon remained to be elucidated.

Keywords: Carcinogenesis; Enterotoxigenic Bacteroides fragilis; IL-17; inflammation; Microbiome

References

  1. Sci Transl Med. 2012 Dec 12;4(164):164ra159 - PubMed
  2. J Clin Invest. 2014 Oct;124(10):4166-72 - PubMed
  3. Science. 2011 May 20;332(6032):974-7 - PubMed
  4. Immunity. 2014 Dec 18;41(6):1052-63 - PubMed
  5. Int J Cancer. 2010 Apr 1;126(7):1651-65 - PubMed
  6. Nature. 2014 Sep 25;513(7519):564-8 - PubMed
  7. Cancer Discov. 2015 Oct;5(10):1098-109 - PubMed
  8. Nat Med. 2009 Sep;15(9):1016-22 - PubMed

Publication Types

Grant support