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Sathiyamurthy S, Banerjee J, Godambe SV. Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review. World J Clin Pediatr. 2016;5(2):159-71doi: 10.5409/wjcp.v5.i2.159.
Sathiyamurthy, S., Banerjee, J., & Godambe, S. V. (2016). Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review. World journal of clinical pediatrics, 5(2), 159-71. https://doi.org/10.5409/wjcp.v5.i2.159
Sathiyamurthy, Sundar, et al. "Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review." World journal of clinical pediatrics vol. 5,2 (2016): 159-71. doi: https://doi.org/10.5409/wjcp.v5.i2.159
Sathiyamurthy S, Banerjee J, Godambe SV. Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review. World J Clin Pediatr. 2016 May 08;5(2):159-71. doi: 10.5409/wjcp.v5.i2.159. eCollection 2016 May 08. PMID: 27170926; PMCID: PMC4857229.
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World J Clin Pediatr. 2016 May 08;5(2):159-71. doi: 10.5409/wjcp.v5.i2.159. eCollection 2016 May 08.

Antiseptic use in the neonatal intensive care unit - a dilemma in clinical practice: An evidence based review.

World journal of clinical pediatrics

Sundar Sathiyamurthy, Jayanta Banerjee, Sunit V Godambe

Affiliations

  1. Sundar Sathiyamurthy, Jayanta Banerjee, Sunit V Godambe, Children's Directorate, Department of Neonatal Medicine, Imperial College Healthcare NHS Trust, London W12 0HS, United Kingdom.

PMID: 27170926 PMCID: PMC4857229 DOI: 10.5409/wjcp.v5.i2.159

Abstract

Infants in the neonatal intensive care unit are highly susceptible to healthcare associated infections (HAI), with a substantial impact on mortality, morbidity and healthcare costs. Effective skin disinfection with topical antiseptic agents is an important intervention in the prevention or reduction of HAI. A wide array of antiseptic preparations in varying concentrations and combinations has been used in neonatal units worldwide. In this article we have reviewed the current evidence of a preferred antiseptic of choice over other agents for topical skin disinfection in neonates. Chlorhexidine (CHG) appears to be a promising antiseptic agent; however there exists a significant concern regarding the safety of all agents used including CHG especially in preterm and very low birth weight infants. There is substantial evidence to support the use of CHG for umbilical cord cleansing and some evidence to support the use of topical emollients in reducing the mortality in infants born in developing countries. Well-designed large multicentre randomized clinical trials are urgently needed to guide us on the most appropriate and safe antiseptic to use in neonates undergoing intensive care, especially preterm infants.

Keywords: Alcohol; Antiseptics; Chlorhexidine; Disinfectants; Neonate; Povidone-iodine; Preterm; Topical; Very low birth weight infant

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