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Charng J, He Z, Vingrys AJ, et al. Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System. J Ophthalmol. 2016;2016:5801826doi: 10.1155/2016/5801826.
Charng, J., He, Z., Vingrys, A. J., Fish, R. L., Gurrell, R., Bui, B. V., & Nguyen, C. T. (2016). Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System. Journal of ophthalmology, 20165801826. https://doi.org/10.1155/2016/5801826
Charng, Jason, et al. "Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System." Journal of ophthalmology vol. 2016 (2016): 5801826. doi: https://doi.org/10.1155/2016/5801826
Charng J, He Z, Vingrys AJ, Fish RL, Gurrell R, Bui BV, Nguyen CT. Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System. J Ophthalmol. 2016;2016:5801826. doi: 10.1155/2016/5801826. Epub 2016 Apr 27. PMID: 27239335; PMCID: PMC4863103.
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J Ophthalmol. 2016;2016:5801826. doi: 10.1155/2016/5801826. Epub 2016 Apr 27.

Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System.

Journal of ophthalmology

Jason Charng, Zheng He, Algis J Vingrys, Rebecca L Fish, Rachel Gurrell, Bang V Bui, Christine T Nguyen

Affiliations

  1. Department of Optometry & Vision Sciences, University of Melbourne, Parkville, VIC 3010, Australia.
  2. Pfizer Neusentis, Cambridge CB21 6GS, UK.

PMID: 27239335 PMCID: PMC4863103 DOI: 10.1155/2016/5801826

Abstract

Objective. To examine whether retinal electrophysiology is a useful surrogate marker of drug penetrance into the central nervous system (CNS). Materials and Methods. Brain and retinal electrophysiology were assessed with full-field visually evoked potentials and electroretinograms in conscious and anaesthetised rats following systemic or local administrations of centrally penetrant (muscimol) or nonpenetrant (isoguvacine) compounds. Results. Local injections into the eye/brain bypassed the blood neural barriers and produced changes in retinal/brain responses for both drugs. In conscious animals, systemic administration of muscimol resulted in retinal and brain biopotential changes, whereas systemic delivery of isoguvacine did not. General anaesthesia confounded these outcomes. Conclusions. Retinal electrophysiology, when recorded in conscious animals, shows promise as a viable biomarker of drug penetration into the CNS. In contrast, when conducted under anaesthetised conditions confounds can be induced in both cortical and retinal electrophysiological recordings.

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