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Ferraro E, Pin F, Gorini S, et al. Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine. J Cachexia Sarcopenia Muscle. 2016;7(4):449-57doi: 10.1002/jcsm.12097.
Ferraro, E., Pin, F., Gorini, S., Pontecorvo, L., Ferri, A., Mollace, V., Costelli, P., & Rosano, G. (2016). Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine. Journal of cachexia, sarcopenia and muscle, 7(4), 449-57. https://doi.org/10.1002/jcsm.12097
Ferraro, Elisabetta, et al. "Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine." Journal of cachexia, sarcopenia and muscle vol. 7,4 (2016): 449-57. doi: https://doi.org/10.1002/jcsm.12097
Ferraro E, Pin F, Gorini S, Pontecorvo L, Ferri A, Mollace V, Costelli P, Rosano G. Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine. J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):449-57. doi: 10.1002/jcsm.12097. Epub 2016 Jan 05. PMID: 27239426; PMCID: PMC4864287.
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J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):449-57. doi: 10.1002/jcsm.12097. Epub 2016 Jan 05.

Improvement of skeletal muscle performance in ageing by the metabolic modulator Trimetazidine.

Journal of cachexia, sarcopenia and muscle

Elisabetta Ferraro, Fabrizio Pin, Stefania Gorini, Laura Pontecorvo, Alberto Ferri, Vincenzo Mollace, Paola Costelli, Giuseppe Rosano

Affiliations

  1. Laboratory of Pathophysiology of Cachexia and Metabolism of Skeletal Muscle IRCCS San Raffaele Pisana Rome Italy.
  2. Department of Clinical and Biological Sciences University of Turin Turin Italy; Istituto Interuniversitario di Miologia-IIM IIM Italy.
  3. Institute of Cell Biology and Neurobiology CNR Rome Italy.
  4. Department of Pharmacobiological Sciences University Magna Graecia Catanzaro Italy.
  5. Laboratory of Pathophysiology of Cachexia and Metabolism of Skeletal MuscleI RCCS San Raffaele Pisana Rome Italy; Cardiovascular and Cell Sciences Institute St George's University of London London UK.

PMID: 27239426 PMCID: PMC4864287 DOI: 10.1002/jcsm.12097

Abstract

BACKGROUND: The loss of muscle mass (sarcopenia) and the associated reduced muscle strength are key limiting factors for elderly people's quality of life. Improving muscle performance does not necessarily correlate with increasing muscle mass. In fact, particularly in the elderly, the main explanation for muscle weakness is a reduction of muscle quality rather than a loss of muscle mass, and the main goal to be achieved is to increase muscle strength. The effectiveness of Trimetazidine (TMZ) in preventing muscle functional impairment during ageing was assessed in our laboratory.

METHODS: Aged mice received TMZ or vehicle for 12 consecutive days. Muscle function was evaluated at the end of the treatment by a grip test as well as by an inverted screen test at 0, 5, 7 and 12 days of TMZ treatment. After sacrifice, muscles were stored for myofiber cross-sectional area assessment and myosin heavy chain expression evaluation by western blotting.

RESULTS: Chronic TMZ treatment does not affect the mass of both gastrocnemius and tibialis anterior muscles, while it significantly increases muscle strength. Indeed, both latency to fall and grip force are markedly enhanced in TMZ-treated versus untreated mice. In addition, TMZ administration results in higher expression of slow myosin heavy chain isoform and increased number of small-sized myofibers.

CONCLUSIONS: We report here some data showing that the modulation of skeletal muscle metabolism by TMZ increases muscle strength in aged mice. Reprogramming metabolism might therefore be a strategy worth to be further investigated in view of improving muscle performance in the elderly.

Keywords: Aging, Exercise pill; Metabolic reprogramming; Neuro‐rehabilitation; Sarcopenia

References

  1. Exp Gerontol. 2008 Jan;43(1):24-33 - PubMed
  2. Osteoporos Int. 2010 Apr;21(4):543-59 - PubMed
  3. J Cachexia Sarcopenia Muscle. 2012 Dec;3(4):213-7 - PubMed
  4. Aging Cell. 2003 Feb;2(1):21-9 - PubMed
  5. Circ Res. 2000 Mar 17;86(5):580-8 - PubMed
  6. J Gerontol A Biol Sci Med Sci. 1995 Nov;50 Spec No:11-6 - PubMed
  7. Nat Methods. 2012 Jul;9(7):671-5 - PubMed
  8. Acta Physiol Scand. 1993 Feb;147(2):227-34 - PubMed
  9. Nutr Rev. 2007 Dec;65(12 Pt 2):S208-12 - PubMed
  10. J Aging Res. 2012;2012:194821 - PubMed
  11. J Gerontol. 1992 May;47(3):B71-6 - PubMed
  12. Int J Cancer. 2012 Jun 1;130(11):2722-7 - PubMed
  13. Muscle Nerve. 2004 Jan;29(1):120-7 - PubMed
  14. FEBS J. 2013 Oct;280(20):5094-108 - PubMed
  15. Am J Epidemiol. 2004 Feb 15;159(4):413-21 - PubMed
  16. Pharmacol Res. 2011 Apr;63(4):278-83 - PubMed
  17. Aging Cell. 2012 Oct;11(5):801-9 - PubMed
  18. Int J Cancer. 2010 Oct 1;127(7):1706-17 - PubMed
  19. J Neurol Sci. 1988 Apr;84(2-3):275-94 - PubMed
  20. Cell. 2013 Jun 6;153(6):1194-217 - PubMed
  21. FASEB J. 2010 May;24(5):1376-90 - PubMed
  22. J Neurol Neurosurg Psychiatry. 1973 Apr;36(2):174-82 - PubMed
  23. J Biomech. 2014 Mar 21;47(5):944-8 - PubMed
  24. Aging Clin Exp Res. 2013 Jun;25(3):291-8 - PubMed
  25. Int J Biochem Cell Biol. 2013 Oct;45(10):2191-9 - PubMed
  26. Eur J Neurosci. 2007 Apr;25(7):2009-20 - PubMed
  27. Mech Ageing Dev. 1991 Oct;60(2):199-213 - PubMed
  28. Am Fam Physician. 2005 Jul 1;72(1):81-8 - PubMed
  29. Curr Aging Sci. 2011 Dec;4(3):260-8 - PubMed
  30. Hum Mol Genet. 2013 Oct 15;22(20):4102-16 - PubMed
  31. J Cachexia Sarcopenia Muscle. 2016 Sep;7(4):449-57 - PubMed
  32. J Clin Invest. 2006 Jan;116(1):33-5 - PubMed
  33. Ageing Res Rev. 2009 Oct;8(4):328-38 - PubMed
  34. Br Med Bull. 2010;95:139-59 - PubMed
  35. J Strength Cond Res. 2012 Jun;26(6):1724-9 - PubMed
  36. Ann N Y Acad Sci. 2000 May;904:437-48 - PubMed
  37. J Vis Exp. 2013 Jun 02;(76): - PubMed
  38. Mol Cell Biol. 2013 Jan;33(2):194-212 - PubMed
  39. Circ Res. 2003 Aug 8;93(3):e33-7 - PubMed
  40. Scand J Med Sci Sports. 2003 Feb;13(1):40-7 - PubMed
  41. PLoS One. 2013 Dec 09;8(12):e81222 - PubMed
  42. Am J Physiol Endocrinol Metab. 2006 Jan;290(1):E54-E59 - PubMed
  43. Science. 2003 Nov 28;302(5650):1575-7 - PubMed
  44. Exp Gerontol. 2010 May;45(5):389-93 - PubMed
  45. Biol Rev Camb Philos Soc. 2011 Aug;86(3):564-600 - PubMed
  46. EMBO Mol Med. 2009 Nov;1(8-9):381-91 - PubMed
  47. Exp Gerontol. 2004 Jan;39(1):17-24 - PubMed
  48. J Cardiovasc Pharmacol Ther. 2004 Sep;9 Suppl 1:S47-64 - PubMed
  49. Antioxid Redox Signal. 2014 Jul 1;21(1):154-76 - PubMed
  50. JAMA. 2001 Sep 12;286(10):1206-12 - PubMed
  51. J Appl Physiol (1985). 2013 Apr;114(7):858-68 - PubMed

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