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Traine PG, Schedler KJ, Rodrigues EB. Clinical Presentation and Genetic Paradigm of Diffuse Infiltrating Retinoblastoma: A Review. Ocul Oncol Pathol. 2015;2(3):128-32doi: 10.1159/000441528.
Traine, P. G., Schedler, K. J., & Rodrigues, E. B. (2016). Clinical Presentation and Genetic Paradigm of Diffuse Infiltrating Retinoblastoma: A Review. Ocular oncology and pathology, 2(3), 128-32. https://doi.org/10.1159/000441528
Traine, Peter G, et al. "Clinical Presentation and Genetic Paradigm of Diffuse Infiltrating Retinoblastoma: A Review." Ocular oncology and pathology vol. 2,3 (2016): 128-32. doi: https://doi.org/10.1159/000441528
Traine PG, Schedler KJ, Rodrigues EB. Clinical Presentation and Genetic Paradigm of Diffuse Infiltrating Retinoblastoma: A Review. Ocul Oncol Pathol. 2016 Apr;2(3):128-32. doi: 10.1159/000441528. Epub 2015 Nov 14. PMID: 27239450; PMCID: PMC4881270.
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Ocul Oncol Pathol. 2016 Apr;2(3):128-32. doi: 10.1159/000441528. Epub 2015 Nov 14.

Clinical Presentation and Genetic Paradigm of Diffuse Infiltrating Retinoblastoma: A Review.

Ocular oncology and pathology

Peter G Traine, Katharina J Schedler, Eduardo B Rodrigues

Affiliations

  1. Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland.
  2. Department of Ophthalmology and Visual Sciences, Federal University of São Paulo, São Paulo, Brazil.

PMID: 27239450 PMCID: PMC4881270 DOI: 10.1159/000441528

Abstract

Retinoblastoma is the most common childhood cancer. Thanks to modern technology and good medical access, mortality in Europe has decreased to about 5%. Diffuse infiltrating retinoblastoma is a very rare subtype of this neoplasm and is characterized by its atypical growth pattern. Diffuse infiltrating retinoblastoma may mimic other more innocuous diseases and may therefore be misdiagnosed. The purpose of this paper was to provide a short review of the main symptoms of diffuse infiltrating retinoblastoma presenting to the ophthalmologist and give a comparison to typical retinoblastoma. The second purpose was to set up a discussion of the genetic paradigm of diffuse infiltrating retinoblastoma. It has often been described to occur sporadically; however, in the last years, it has been shown that it might be heritable. A literature search concerning diffuse infiltrating retinoblastoma considering English, German and Spanish cases and case series identified 77 patients. Moreover, an overview of general data, main symptoms, clinical findings and initial working diagnoses or referral diagnoses is given. Males were significantly more often affected than females. Diffuse infiltrating retinoblastoma can be heritable. Genetic analysis should be offered to the patient and relatives. Interdisciplinary medical follow-up care is needed to detect associated cancers.

Keywords: Childhood cancer; Diffuse infiltrating retinoblastoma; Genetics; Retina; Retinoblastoma

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