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Koppara A, Wagner M, Lange C, et al. Cognitive performance before and after the onset of subjective cognitive decline in old age. Alzheimers Dement (Amst). 2015;1(2):194-205doi: 10.1016/j.dadm.2015.02.005.
Koppara, A., Wagner, M., Lange, C., Ernst, A., Wiese, B., König, H. H., Brettschneider, C., Riedel-Heller, S., Luppa, M., Weyerer, S., Werle, J., Bickel, H., Mösch, E., Pentzek, M., Fuchs, A., Wolfsgruber, S., Beauducel, A., Scherer, M., Maier, W., & Jessen, F. (2015). Cognitive performance before and after the onset of subjective cognitive decline in old age. Alzheimer's & dementia (Amsterdam, Netherlands), 1(2), 194-205. https://doi.org/10.1016/j.dadm.2015.02.005
Koppara, Alexander, et al. "Cognitive performance before and after the onset of subjective cognitive decline in old age." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 1,2 (2015): 194-205. doi: https://doi.org/10.1016/j.dadm.2015.02.005
Koppara A, Wagner M, Lange C, Ernst A, Wiese B, König HH, Brettschneider C, Riedel-Heller S, Luppa M, Weyerer S, Werle J, Bickel H, Mösch E, Pentzek M, Fuchs A, Wolfsgruber S, Beauducel A, Scherer M, Maier W, Jessen F. Cognitive performance before and after the onset of subjective cognitive decline in old age. Alzheimers Dement (Amst). 2015 May 02;1(2):194-205. doi: 10.1016/j.dadm.2015.02.005. eCollection 2015 Jun. PMID: 27239504; PMCID: PMC4876897.
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Alzheimers Dement (Amst). 2015 May 02;1(2):194-205. doi: 10.1016/j.dadm.2015.02.005. eCollection 2015 Jun.

Cognitive performance before and after the onset of subjective cognitive decline in old age.

Alzheimer's & dementia (Amsterdam, Netherlands)

Alexander Koppara, Michael Wagner, Carolin Lange, Annette Ernst, Birgitt Wiese, Hans-Helmut König, Christian Brettschneider, Steffi Riedel-Heller, Melanie Luppa, Siegfried Weyerer, Jochen Werle, Horst Bickel, Edelgard Mösch, Michael Pentzek, Angela Fuchs, Steffen Wolfsgruber, André Beauducel, Martin Scherer, Wolfgang Maier, Frank Jessen

Affiliations

  1. Department of Psychiatry and Psychotherapy, Rheinische-Friedrich-Wilhelms University, Bonn, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.
  2. Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  3. Instiute of General Practice, WG Medical Statistics and IT-Infrastructure, Hannover Medical School, Hannover, Germany.
  4. Department of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  5. Department of Psychiatry, University of Leipzig, Leipzig, Germany.
  6. Department of Psychiatry and Psychotherapy, Psychiatric Epidemiology and Demographic Change, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
  7. Department of Psychiatry, Technical University, Munich, Germany.
  8. Department of General Practice, University Medical Center Düsseldorf, Düsseldorf, Germany.
  9. Institute of Psychology, Methods, Assessment, & Evaluation, Rheinische-Friedrich-Wilhelms University, Bonn, Germany.
  10. Department of Psychiatry, University of Cologne, Medical Faculty, Cologne, Germany; German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.

PMID: 27239504 PMCID: PMC4876897 DOI: 10.1016/j.dadm.2015.02.005

Abstract

BACKGROUND: Our objectives were (1) to test the association between the report of subjective cognitive decline (SCD) and prospective objective cognitive performance in high age individuals and (2) to study the course of longitudinal cognitive performance before and after the first report of SCD.

METHODS: Cognitively normal elderly participants of the German Study on Ageing, Cognition, and Dementia study (N = 2330) with SCD (subjective decline in memory with and without associated concerns) and without SCD at baseline were assessed over 8 years with regard to immediate and delayed verbal recall, verbal fluency, working memory, and global cognition. Baseline performance and cognitive trajectories were compared between groups. In addition, cognitive trajectories before and after the initial report of SCD (incident SCD) were modelled in those without SCD at baseline.

RESULTS: Baseline performance in the SCD group was lower and declined more steeply in immediate and delayed verbal recall than in the control group (no SCD at baseline). This effect was more pronounced in the SCD group with concerns. Incident SCD was preceded by decline in immediate and delayed memory and word fluency.

CONCLUSIONS: SCD predicts future memory decline. Incident SCD is related to previous cognitive decline. The latter finding supports the concept of SCD indicating first subtle decline in cognitive performance that characterizes preclinical Alzheimer's disease.

Keywords: Early detection; Preclinical Alzheimer's disease; Subjective cognitive decline

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