Display options
Cite
Schoemaker D, Poirier J, Escobar S, et al. Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. Alzheimers Dement (Amst). 2015;2:132-9doi: 10.1016/j.dadm.2015.11.007.
Schoemaker, D., Poirier, J., Escobar, S., Gauthier, S., & Pruessner, J. (2016). Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. Alzheimer's & dementia (Amsterdam, Netherlands), 2132-9. https://doi.org/10.1016/j.dadm.2015.11.007
Schoemaker, Dorothee, et al. "Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease." Alzheimer's & dementia (Amsterdam, Netherlands) vol. 2 (2016): 132-9. doi: https://doi.org/10.1016/j.dadm.2015.11.007
Schoemaker D, Poirier J, Escobar S, Gauthier S, Pruessner J. Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease. Alzheimers Dement (Amst). 2015 Dec 23;2:132-9. doi: 10.1016/j.dadm.2015.11.007. eCollection 2016. PMID: 27239534; PMCID: PMC4879663.
Copy Download .nbib Format: NLM
Share it on

Alzheimers Dement (Amst). 2015 Dec 23;2:132-9. doi: 10.1016/j.dadm.2015.11.007. eCollection 2016.

Selective familiarity deficits in otherwise cognitively intact aging individuals with genetic risk for Alzheimer's disease.

Alzheimer's & dementia (Amsterdam, Netherlands)

Dorothee Schoemaker, Judes Poirier, Sophia Escobar, Serge Gauthier, Jens Pruessner

Affiliations

  1. McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada; Douglas Hospital Research Centre, Montreal, QC, Canada.
  2. Douglas Hospital Research Centre, Montreal, QC, Canada.
  3. McGill Centre for Studies in Aging, McGill University, Montreal, QC, Canada.

PMID: 27239534 PMCID: PMC4879663 DOI: 10.1016/j.dadm.2015.11.007

Abstract

INTRODUCTION: Familiarity has been associated with integrity of the rhinal cortex. Thus, impairment in familiarity is expected in very early stages of Alzheimer's disease (AD). The apolipoprotein E (APOE) ε4 allele is a major risk factor for AD. Here, we investigated the effect of the APOE ε4 status on familiarity in cognitively normal aging individuals.

METHODS: Eighty-one individuals aged between 55 and 80 years, 21 carriers and 60 noncarriers, were used in these analyses. A cognitive evaluation was performed on all participants to document the absence of objective cognitive deficits. The effect of APOE ε4 status on familiarity was tested using independent sample t test and an analysis of covariance controlling for age, gender, and education.

RESULTS: The groups did not differ in term of age, education, and male/female ratio. APOE ε4 carriers showed a significant reduction in familiarity. No other cognitive deficit was observed in the group of ε4 carriers, relative to noncarriers.

DISCUSSION: APOE ε4 is associated with a reduction in familiarity in the absence of other cognitive deficits. These results suggest that performance in familiarity could represent an early cognitive marker for individuals at risk of AD.

Keywords: Aging; Alzheimer's disease; Apolipoprotein E; Cognitive marker; Familiarity; Recollection

References

  1. Proc Natl Acad Sci U S A. 2001 Sep 11;98 (19):10966-71 - PubMed
  2. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11661-6 - PubMed
  3. Neuropsychol Rev. 2014 Sep;24(3):313-31 - PubMed
  4. Proc Natl Acad Sci U S A. 1995 May 23;92(11):4725-7 - PubMed
  5. Neuropsychology. 2005 Mar;19(2):199-211 - PubMed
  6. Hippocampus. 2009 Nov;19(11):1055-64 - PubMed
  7. Neuropsychologia. 2011 Aug;49(10 ):2856-65 - PubMed
  8. Memory. 1997 Nov;5(6):657-72 - PubMed
  9. Neuropsychologia. 2004;42(1):2-13 - PubMed
  10. Arch Neurol. 1995 Nov;52(11):1074-9 - PubMed
  11. Lancet. 1995 Nov 25;346(8987):1387-90 - PubMed
  12. Neuropsychology. 2010 Jan;24(1):49-67 - PubMed
  13. Acta Neuropathol. 1991;82(4):239-59 - PubMed
  14. J Am Geriatr Soc. 2005 Apr;53(4):695-9 - PubMed
  15. Ann Neurol. 1996 Dec;40(6):829-40 - PubMed
  16. Neuropsychologia. 2011 Jun;49(7):1870-8 - PubMed
  17. Neuropsychol Rev. 2014 Sep;24(3):332-54 - PubMed
  18. Neuropsychologia. 2012 Jul;50(9):2333-40 - PubMed
  19. J Psychiatr Res. 1975 Nov;12(3):189-98 - PubMed
  20. Neurology. 2001 Jul 10;57(1):89-95 - PubMed
  21. Alzheimers Dement. 2007 Jul;3(3):186-91 - PubMed
  22. Arch Clin Neuropsychol. 1999 Feb;14(2):167-77 - PubMed
  23. J Neurosci. 1996 Jul 15;16(14):4491-500 - PubMed
  24. Neurology. 2000 Jun 13;54(11):2082-8 - PubMed
  25. Ann Neurol. 1994 Dec;36(6):889-95 - PubMed
  26. Cereb Cortex. 2006 Dec;16(12):1771-82 - PubMed
  27. Behav Res Methods. 2010 Feb;42(1):351-62 - PubMed
  28. Hum Genet. 1999 Feb;104(2):158-63 - PubMed
  29. Neurobiol Aging. 1998 Jan-Feb;19(1):15-22 - PubMed
  30. Cereb Cortex. 1998 Sep;8(6):492-509 - PubMed
  31. Science. 1993 Aug 13;261(5123):921-3 - PubMed
  32. Lancet. 1993 Sep 18;342(8873):697-9 - PubMed
  33. Neuropsychologia. 2010 Jul;48(9):2640-7 - PubMed
  34. J Alzheimers Dis. 2009;18(3):553-64 - PubMed
  35. Nat Rev Neurol. 2013 Feb;9(2):106-18 - PubMed
  36. Lancet Neurol. 2013 Feb;12(2):207-16 - PubMed
  37. J Psychiatr Res. 1982-1983;17(1):37-49 - PubMed
  38. Neurology. 1998 Feb;50(2):355-62 - PubMed

Publication Types