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Chen R, Qi J, Mao Z, et al. Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines. Org Biomol Chem. 2016;14(26):6201-4doi: 10.1039/c6ob00942e.
Chen, R., Qi, J., Mao, Z., & Cui, S. (2016). Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines. Organic & biomolecular chemistry, 14(26), 6201-4. https://doi.org/10.1039/c6ob00942e
Chen, Renjie, et al. "Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines." Organic & biomolecular chemistry vol. 14,26 (2016): 6201-4. doi: https://doi.org/10.1039/c6ob00942e
Chen R, Qi J, Mao Z, Cui S. Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines. Org Biomol Chem. 2016 Jul 14;14(26):6201-4. doi: 10.1039/c6ob00942e. Epub 2016 Jun 08. PMID: 27273816.
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Org Biomol Chem. 2016 Jul 14;14(26):6201-4. doi: 10.1039/c6ob00942e. Epub 2016 Jun 08.

Rh(iii)-catalyzed C-H activation/cyclization of oximes with alkenes for regioselective synthesis of isoquinolines.

Organic & biomolecular chemistry

Renjie Chen, Jifeng Qi, Zhenjun Mao, Sunliang Cui

Affiliations

  1. Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, P. R. China. [email protected].

PMID: 27273816 DOI: 10.1039/c6ob00942e

Abstract

A Rh(iii)-catalyzed C-H activation/cyclization of oximes and alkenes for facile and regioselective access to isoquinolines has been developed. This protocol features mild reaction conditions and easily accessible starting materials, and has been applied to the concise synthesis of moxaverine. A kinetic isotope effect study was conducted and a plausible mechanism was proposed.

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