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Jia P, Huang Y. Sequential Annulation Domino Reaction of Sulfur Ylides and α,β-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines. Org Lett. 2016;18(10):2475-8doi: 10.1021/acs.orglett.6b01045.
Jia, P., & Huang, Y. (2016). Sequential Annulation Domino Reaction of Sulfur Ylides and α,β-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines. Organic letters, 18(10), 2475-8. https://doi.org/10.1021/acs.orglett.6b01045
Jia, Penghao, and Huang, You. "Sequential Annulation Domino Reaction of Sulfur Ylides and α,β-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines." Organic letters vol. 18,10 (2016): 2475-8. doi: https://doi.org/10.1021/acs.orglett.6b01045
Jia P, Huang Y. Sequential Annulation Domino Reaction of Sulfur Ylides and α,β-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines. Org Lett. 2016 May 20;18(10):2475-8. doi: 10.1021/acs.orglett.6b01045. Epub 2016 May 12. PMID: 27171382.
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Org Lett. 2016 May 20;18(10):2475-8. doi: 10.1021/acs.orglett.6b01045. Epub 2016 May 12.

Sequential Annulation Domino Reaction of Sulfur Ylides and α,β-Unsaturated Cyclic Ketimines: Synthesis of Cyclic 2-Alkenyl Aziridines.

Organic letters

Penghao Jia, You Huang

Affiliations

  1. State Key Laboratory and Institute of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.
  2. Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) , Tianjin 300071, China.

PMID: 27171382 DOI: 10.1021/acs.orglett.6b01045

Abstract

A sequential annulation domino reaction of sulfur ylides and α,β-unsaturated cyclic ketimines for the construction of cyclic 2-alkenyl aziridines has been developed. Readily accessible starting materials, a one-pot procedure, excellent functional group compatibility, and mild conditions make this transformation a powerful tool for the synthesis of cyclic 2-alkenyl aziridines.

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