Display options
Cite
Nagy K, Nagaraju SP, Rhee CM, et al. Adipocytokines in renal transplant recipients. Clin Kidney J. 2016;9(3):359-73doi: 10.1093/ckj/sfv156.
Nagy, K., Nagaraju, S. P., Rhee, C. M., Mathe, Z., & Molnar, M. Z. (2016). Adipocytokines in renal transplant recipients. Clinical kidney journal, 9(3), 359-73. https://doi.org/10.1093/ckj/sfv156
Nagy, Kristof, et al. "Adipocytokines in renal transplant recipients." Clinical kidney journal vol. 9,3 (2016): 359-73. doi: https://doi.org/10.1093/ckj/sfv156
Nagy K, Nagaraju SP, Rhee CM, Mathe Z, Molnar MZ. Adipocytokines in renal transplant recipients. Clin Kidney J. 2016 Jun;9(3):359-73. doi: 10.1093/ckj/sfv156. Epub 2016 Mar 15. PMID: 27274819; PMCID: PMC4886901.
Copy Download .nbib Format: NLM
Share it on

Clin Kidney J. 2016 Jun;9(3):359-73. doi: 10.1093/ckj/sfv156. Epub 2016 Mar 15.

Adipocytokines in renal transplant recipients.

Clinical kidney journal

Kristof Nagy, Shankar Prasad Nagaraju, Connie M Rhee, Zoltan Mathe, Miklos Z Molnar

Affiliations

  1. Department of Transplantation and Surgery , Semmelweis University , Budapest , Hungary.
  2. Department of Nephrology, Kasturba Medical College , Manipal University , Manipal , India.
  3. Harold Simmons Center for Chronic Disease Research and Epidemiology, Division of Nephrology and Hypertension , University of California Irvine , Orange, CA , USA.
  4. Division of Nephrology, Department of Medicine , University of Tennessee Health Science Center , Memphis, TN , USA.

PMID: 27274819 PMCID: PMC4886901 DOI: 10.1093/ckj/sfv156

Abstract

In the last two decades, perceptions about the role of body fat have changed. Adipocytes modulate endocrine and immune homeostasis by synthesizing hundreds of hormones, known as adipocytokines. Many studies have been investigating the influences and effects of these adipocytokines and suggest that they are modulated by the nutritional and immunologic milieu. Kidney transplant recipients (KTRs) are a unique and relevant population in which the function of adipocytokines can be examined, given their altered nutritional and immune status and subsequent dysregulation of adipocytokine metabolism. In this review, we summarize the recent findings about four specific adipocytokines and their respective roles in KTRs. We decided to evaluate the most widely described adipocytokines, including leptin, adiponectin, visfatin and resistin. Increasing evidence suggests that these adipocytokines may lead to cardiovascular events and metabolic changes in the general population and may also increase mortality and graft loss rate in KTRs. In addition, we present findings on the interrelationship between serum adipocytokine levels and nutritional and immunologic status, and mechanisms by which adipocytokines modulate morbidity and outcomes in KTRs.

Keywords: adiponectin; kidney transplantation; leptin; resistin; visfatin

References

  1. Nat Med. 2004 May;10(5):524-9 - PubMed
  2. Niger J Clin Pract. 2014 Nov-Dec;17 (6):735-8 - PubMed
  3. Am J Physiol Renal Physiol. 2013 Dec 15;305(12):F1629-36 - PubMed
  4. Circ J. 2007 May;71(5):623-30 - PubMed
  5. Metabolism. 2015 Feb;64(2):202-7 - PubMed
  6. Rev Endocr Metab Disord. 2014 Jun;15(2):157-67 - PubMed
  7. Transplant Proc. 2011 Sep;43(7):2601-5 - PubMed
  8. Metabolism. 2007 Sep;56(9):1201-8 - PubMed
  9. Semin Dial. 2007 Nov-Dec;20(6):534-8 - PubMed
  10. Endocr Res. 2005;31(1):27-37 - PubMed
  11. J Clin Endocrinol Metab. 2007 Feb;92 (2):666-72 - PubMed
  12. Nephrol Dial Transplant. 1998 Sep;13(9):2276-80 - PubMed
  13. Endocr Res. 2011;36(3):93-100 - PubMed
  14. Clin J Am Soc Nephrol. 2010 Dec;5(12):2297-304 - PubMed
  15. PLoS One. 2013 Oct 10;8(10):e78283 - PubMed
  16. Transplantation. 2005 Dec 27;80(12):1660-6 - PubMed
  17. J Endocrinol. 1997 Dec;155(3):577-85 - PubMed
  18. Transplantation. 2004 Jul 15;78(1):26-30 - PubMed
  19. Cytokine. 2013 Oct;64(1):1-10 - PubMed
  20. Nature. 1998 Aug 27;394(6696):897-901 - PubMed
  21. Obesity (Silver Spring). 2007 Jun;15(6):1617-22 - PubMed
  22. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv15-22 - PubMed
  23. J Ren Nutr. 2008 Jan;18(1):154-7 - PubMed
  24. Clin Invest Med. 2015 May 31;38(3):E100-9 - PubMed
  25. Nephrol Dial Transplant. 2011 Jun;26(6):2000-6 - PubMed
  26. Transpl Int. 2016 Mar;29(3):352-61 - PubMed
  27. Transplant Proc. 2012 Apr;44(3):676-9 - PubMed
  28. Clin Sci (Lond). 2005 Sep;109(3):243-56 - PubMed
  29. Cardiovasc Res. 2008 May 1;78(2):356-65 - PubMed
  30. Mol Biotechnol. 1999 Apr;11(2):149-58 - PubMed
  31. Transplant Proc. 2005 Nov;37(9):3808-12 - PubMed
  32. J Ren Nutr. 2012 Jul;22(4):440-9 - PubMed
  33. Am J Kidney Dis. 2007 Feb;49(2):237-44 - PubMed
  34. Basic Clin Pharmacol Toxicol. 2014 Jan;114(1):97-102 - PubMed
  35. Transplant Proc. 2010 Apr;42(3):797-800 - PubMed
  36. Perit Dial Int. 1998 Jan-Feb;18(1):34-40 - PubMed
  37. J Biol Chem. 2004 Aug 13;279(33):34302-10 - PubMed
  38. Int J Obes (Lond). 2005 Dec;29(12 ):1395-401 - PubMed
  39. Keio J Med. 2011;60(1):1-9 - PubMed
  40. Biochim Biophys Acta. 2010 Dec;1801(12):1294-304 - PubMed
  41. Am J Physiol Renal Physiol. 2008 Nov;295(5):F1485-94 - PubMed
  42. Am J Transplant. 2013 Jan;13(1):36-44 - PubMed
  43. Pol J Pharmacol. 2004 Mar-Apr;56(2):213-22 - PubMed
  44. Biomed Environ Sci. 2015 Mar;28(3):169-77 - PubMed
  45. Nephrology (Carlton). 2010 Mar;15(2):190-6 - PubMed
  46. Nat Med. 2008 Jan;14(1):88-92 - PubMed
  47. Am J Physiol. 1997 Nov;273(5 Pt 1):E903-7 - PubMed
  48. Biochim Biophys Acta. 2008 May;1783(5):886-95 - PubMed
  49. Clin Transplant. 2013 Jul-Aug;27(4):562-6 - PubMed
  50. Transpl Immunol. 2006 Jan;15(3):241-5 - PubMed
  51. Am J Kidney Dis. 2005 Oct;46(4):628-34 - PubMed
  52. J Intern Med. 2011 Feb;269(2):172-81 - PubMed
  53. Iran J Kidney Dis. 2013 Nov;7(6):446-52 - PubMed
  54. FEBS Lett. 1997 Mar 10;404(2-3):185-91 - PubMed
  55. J Cell Biol. 2013 Jul 8;202(1):113-27 - PubMed
  56. Metabolism. 2014 Nov;63(11):1409-18 - PubMed
  57. J Clin Endocrinol Metab. 2012 Jan;97(1):E129-35 - PubMed
  58. J Biol Chem. 2001 Feb 16;276(7):4747-55 - PubMed
  59. Clin Transplant. 2011 Jul-Aug;25(4):561-8 - PubMed
  60. Am J Nephrol. 2013;37(5):399-404 - PubMed
  61. Transplant Proc. 2014;46(2):353-8 - PubMed
  62. Am J Kidney Dis. 2011 Jul;58(1):101-8 - PubMed
  63. J Endocrinol. 2014 May 12;221(2):R49-61 - PubMed
  64. Diabetologia. 2009 Nov;52(11):2455-63 - PubMed
  65. J Pak Med Assoc. 2010 Nov;60(11):922-6 - PubMed
  66. J Surg Res. 2013 Jan;179(1):175-82 - PubMed
  67. Int Urol Nephrol. 2014 Jun;46(6):1169-74 - PubMed
  68. Nephrol Dial Transplant. 2010 Mar;25(3):901-6 - PubMed
  69. Clin J Am Soc Nephrol. 2011 Dec;6(12):2879-86 - PubMed
  70. J Clin Endocrinol Metab. 1996 Sep;81(9):3419-23 - PubMed
  71. J Clin Invest. 1997 May 15;99(10):2398-404 - PubMed
  72. Metabolism. 2004 May;53(5):614-9 - PubMed
  73. Nephron Clin Pract. 2009;113(1):c16-23 - PubMed
  74. Clin Transplant. 2003 Feb;17(1):63-8 - PubMed
  75. Transplant Proc. 2000 Sep;32(6):1331-2 - PubMed
  76. Ren Fail. 2013;35(10):1399-403 - PubMed
  77. Nat Rev Immunol. 2006 Oct;6(10):772-83 - PubMed
  78. Clin Nephrol. 2007 Jun;67(6):381-90 - PubMed
  79. Cardiovasc Res. 2009 Feb 1;81(2):370-80 - PubMed
  80. Transplant Proc. 2009 Jan-Feb;41(1):150-3 - PubMed
  81. Transplant Proc. 2005 Jun;37(5):2151-3 - PubMed
  82. Circulation. 2004 Nov 23;110(21):3335-40 - PubMed
  83. FASEB J. 2000 Nov;14(14):2329-38 - PubMed
  84. J Hum Hypertens. 2015 Feb;29(2):127-33 - PubMed
  85. Transplant Proc. 2011 Jun;43(5):1607-11 - PubMed
  86. Diabetes Metab Syndr Obes. 2011;4:175-86 - PubMed
  87. Diabetes. 2005 Oct;54(10):2911-6 - PubMed
  88. Pharmacogenomics. 2015;16(11):1243-51 - PubMed
  89. J Clin Endocrinol Metab. 2006 Aug;91(8):3165-70 - PubMed
  90. Nephrol Dial Transplant. 2008 Mar;23(3):959-65 - PubMed
  91. Am J Transplant. 2010 Dec;10(12):2644-51 - PubMed
  92. Adipocyte. 2012 Jul 1;1(3):177-181 - PubMed
  93. J Clin Endocrinol Metab. 2008 Jul;93(7):2647-53 - PubMed
  94. Nephrology (Carlton). 2008 Oct;13(5):405-10 - PubMed
  95. Ren Fail. 2008;30(6):617-23 - PubMed
  96. Biochem Biophys Res Commun. 1998 Jun 18;247(2):504-9 - PubMed
  97. Nephrol Dial Transplant. 2010 Dec;25(12):4017-23 - PubMed
  98. Diabetes. 2004 Jul;53(7):1671-9 - PubMed
  99. Clin Chem Lab Med. 2015 Apr;53(5):793-9 - PubMed
  100. Nephrol Dial Transplant. 2009 Sep;24(9):2832-8 - PubMed
  101. Transpl Int. 2012 Nov;25(11):1194-203 - PubMed
  102. Diabetes Metab J. 2013 Dec;37(6):404-14 - PubMed
  103. Inflamm Bowel Dis. 2006 Feb;12(2):100-5 - PubMed
  104. Clin Transplant. 2012 Mar-Apr;26(2):259-66 - PubMed
  105. Am J Physiol Renal Physiol. 2002 May;282(5):F777-84 - PubMed
  106. Eur J Endocrinol. 2010 Feb;162(2):281-8 - PubMed
  107. Am J Kidney Dis. 2003 Jul;42(1):62-6 - PubMed
  108. Nephrology (Carlton). 2007 Jun;12(3):246-53 - PubMed
  109. Transplant Proc. 2014 Oct;46(8):2622-6 - PubMed
  110. Transpl Immunol. 2013 Jan;28(1):18-23 - PubMed
  111. Regul Pept. 2012 Oct 10;178(1-3):11-5 - PubMed
  112. J Bone Miner Res. 2010 Aug;25(8):1711-23 - PubMed
  113. Nephrol Dial Transplant. 1998 Sep;13(9):2271-5 - PubMed
  114. Diabetes. 2009 Sep;58(9):2093-9 - PubMed
  115. J Nephrol. 2010 Jan-Feb;23(1):77-84 - PubMed
  116. Am J Transplant. 2004 Jun;4(6):905-13 - PubMed
  117. Transplant Proc. 2014;46(2):381-4 - PubMed
  118. Clin Endocrinol (Oxf). 2013 Aug;79(2):204-10 - PubMed
  119. Am J Clin Nutr. 2007 Apr;85(4):1121-6 - PubMed
  120. Nature. 2001 Jan 18;409(6818):307-12 - PubMed
  121. Endokrynol Pol. 2010 Jan-Feb;61(1):36-41 - PubMed
  122. J Korean Med Sci. 2012 Apr;27(4):377-81 - PubMed
  123. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv181-7 - PubMed
  124. Kidney Int. 1998 May;53(5):1430-1 - PubMed
  125. Circulation. 2007 Feb 27;115(8):972-80 - PubMed
  126. Clin Lab. 2013;59(9-10):1121-8 - PubMed
  127. J Immunol. 2007 Feb 1;178(3):1748-58 - PubMed
  128. Am J Kidney Dis. 2010 Jul;56(1):102-11 - PubMed
  129. J Hepatol. 2005 May;42(5):666-73 - PubMed
  130. J Renal Inj Prev. 2013 Jun 01;2(2):55-7 - PubMed
  131. Int J Artif Organs. 2014 May;37(5):358-63 - PubMed
  132. Am J Physiol Endocrinol Metab. 2003 Sep;285(3):E527-33 - PubMed
  133. Am J Nephrol. 1999;19(1):28-33 - PubMed
  134. Blood. 1997 Nov 1;90(9):3438-43 - PubMed
  135. Transplant Proc. 2008 Dec;40(10):3466-9 - PubMed
  136. Am J Kidney Dis. 2015 Aug;66(2):313-21 - PubMed
  137. Pflugers Arch. 2007 Sep;454(6):971-6 - PubMed
  138. J Nephrol. 2011 Mar-Apr;24(2):177-84 - PubMed
  139. Best Pract Res Clin Endocrinol Metab. 2014 Jan;28(1):25-31 - PubMed
  140. Clin J Am Soc Nephrol. 2013 Mar;8(3):460-7 - PubMed
  141. Transplantation. 2013 Dec 27;96(12):1059-64 - PubMed
  142. FASEB J. 1998 Jan;12(1):57-65 - PubMed
  143. Z Rheumatol. 2013 Aug;72(6):594-600 - PubMed
  144. Nephrology (Carlton). 2015 Jun;20(6):392-8 - PubMed
  145. Acta Physiol Hung. 2007 Mar;94(1-2):149-57 - PubMed
  146. J Pharmacol Exp Ther. 2005 Dec;315(3):1075-84 - PubMed
  147. Cytokine. 2014 Feb;65(2):159-66 - PubMed
  148. J Am Coll Cardiol. 2009 Mar 3;53(9):754-62 - PubMed
  149. Biochemistry. 2003 Sep 16;42(36):10554-9 - PubMed
  150. Atherosclerosis. 2005 Oct;182(2):241-8 - PubMed
  151. Obesity (Silver Spring). 2013 Mar;21(3):546-52 - PubMed
  152. Transplantation. 2011 Apr 27;91(8):875-82 - PubMed
  153. Metabolism. 2011 Feb;60(2):173-9 - PubMed
  154. Asian Pac J Trop Med. 2014 Jan;7(1):55-62 - PubMed
  155. Am J Physiol. 1997 Mar;272(3 Pt 2):F333-8 - PubMed
  156. Transplantation. 2009 Oct 27;88(8):1030-7 - PubMed
  157. Science. 2004 May 21;304(5674):1154-8 - PubMed
  158. Clin Transplant. 2010 Jul-Aug;24(4):E124-9 - PubMed
  159. Iran J Kidney Dis. 2013 Jul;7(4):304-8 - PubMed
  160. Biochem Biophys Res Commun. 2003 Jan 10;300(2):247-52 - PubMed
  161. Eur J Intern Med. 2010 Dec;21(6):530-5 - PubMed
  162. Am J Transplant. 2007 Feb;7(2):416-22 - PubMed
  163. Metabolism. 2010 Jan;59(1):93-9 - PubMed
  164. Clin Kidney J. 2012 Apr;5(2):124-129 - PubMed
  165. Int J Obes Relat Metab Disord. 1996 Dec;20(12):1120-6 - PubMed
  166. Clin Exp Nephrol. 2015 Jun;19(3):534-41 - PubMed
  167. J Nephrol. 2013 Nov-Dec;26(6):1049-54 - PubMed
  168. Best Pract Res Clin Endocrinol Metab. 2014 Jan;28(1):59-69 - PubMed
  169. J Ren Nutr. 2011 Jan;21(1):72-5 - PubMed
  170. J Biol Chem. 2008 Dec 12;283(50):34833-43 - PubMed
  171. Maturitas. 2014 Sep;79(1):86-90 - PubMed
  172. Int J Biochem Cell Biol. 2014 May;50:29-37 - PubMed
  173. Endocrinology. 2004 Aug;145(8):3935-40 - PubMed
  174. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14568-73 - PubMed
  175. Kidney Int. 1999 Mar;55(3):1129-30 - PubMed
  176. Nephrol Dial Transplant. 2009 Dec;24(12):3626-31 - PubMed
  177. Circ Res. 2007 Sep 14;101(6):545-59 - PubMed
  178. Endocrinology. 2005 Jan;146(1):273-9 - PubMed
  179. Immunity. 2007 Feb;26(2):241-55 - PubMed
  180. Clin Transplant. 2009 Mar-Apr;23(2):241-8 - PubMed
  181. Am J Nephrol. 2009;29(1):31-5 - PubMed
  182. Diabetologia. 2006 Apr;49(4):744-7 - PubMed
  183. Regul Pept. 2011 Apr 11;167(2-3):192-200 - PubMed
  184. Osteoporos Int. 2008 Jul;19(7):905-12 - PubMed
  185. J Transl Med. 2013 Sep 26;11:233 - PubMed
  186. Isr Med Assoc J. 2002 Mar;4(3):213-7 - PubMed
  187. J Pediatr. 2012 Dec;161(6):1022-7 - PubMed
  188. BMC Nephrol. 2009 Oct 12;10:29 - PubMed
  189. Arterioscler Thromb Vasc Biol. 2003 Jan 1;23(1):85-9 - PubMed
  190. Nephrol Dial Transplant. 2013 Nov;28 Suppl 4:iv8-14 - PubMed
  191. Transplant Proc. 2007 Mar;39(2):439-40 - PubMed
  192. Diabetes Metab Syndr. 2012 Apr-Jun;6(2):120-4 - PubMed
  193. Am J Nephrol. 2005 May-Jun;25(3):203-10 - PubMed
  194. PLoS One. 2014 Apr 01;9(4):e93545 - PubMed
  195. Biotech Histochem. 2015 May;90(4):270-7 - PubMed
  196. Diabetes. 2002 Jan;51(1):168-73 - PubMed
  197. Transplant Proc. 2005 Sep;37(7):3106-8 - PubMed
  198. Hemodial Int. 2014 Jan;18(1):153-62 - PubMed
  199. J Clin Hypertens (Greenwich). 2007 Oct;9(10):775-82 - PubMed
  200. Blood Purif. 2005;23(6):421-8 - PubMed
  201. Transpl Int. 2009 Jul;22(7):694-701 - PubMed
  202. Transplant Proc. 2006 Dec;38(10):3434-6 - PubMed
  203. Circulation. 2005 Feb 22;111(7):932-9 - PubMed
  204. Saudi J Kidney Dis Transpl. 2006 Dec;17(4):521-5 - PubMed
  205. Transplant Proc. 2003 Sep;35(6):2186-9 - PubMed
  206. Nephrol Dial Transplant. 2010 Oct;25(10):3236-40 - PubMed
  207. Ann Transplant. 2013 Nov 04;18:593-603 - PubMed
  208. J Clin Invest. 2008 May;118(5):1645-56 - PubMed
  209. Kidney Int. 2001 Apr;59(4):1315-23 - PubMed
  210. Kidney Int. 2006 Feb;69(3):596-604 - PubMed
  211. Med Sci Monit. 2002 Jun;8(6):BR221-9 - PubMed

Publication Types