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Henderson-Smith A, Corneveaux JJ, De Both M, et al. Next-generation profiling to identify the molecular etiology of Parkinson dementia. Neurol Genet. 2016;2(3):e75doi: 10.1212/NXG.0000000000000075.
Henderson-Smith, A., Corneveaux, J. J., De Both, M., Cuyugan, L., Liang, W. S., Huentelman, M., Adler, C., Driver-Dunckley, E., Beach, T. G., & Dunckley, T. L. (2016). Next-generation profiling to identify the molecular etiology of Parkinson dementia. Neurology. Genetics, 2(3), e75. https://doi.org/10.1212/NXG.0000000000000075
Henderson-Smith, Adrienne, et al. "Next-generation profiling to identify the molecular etiology of Parkinson dementia." Neurology. Genetics vol. 2,3 (2016): e75. doi: https://doi.org/10.1212/NXG.0000000000000075
Henderson-Smith A, Corneveaux JJ, De Both M, Cuyugan L, Liang WS, Huentelman M, Adler C, Driver-Dunckley E, Beach TG, Dunckley TL. Next-generation profiling to identify the molecular etiology of Parkinson dementia. Neurol Genet. 2016 May 24;2(3):e75. doi: 10.1212/NXG.0000000000000075. eCollection 2016 Jun. PMID: 27275011; PMCID: PMC4881621.
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Neurol Genet. 2016 May 24;2(3):e75. doi: 10.1212/NXG.0000000000000075. eCollection 2016 Jun.

Next-generation profiling to identify the molecular etiology of Parkinson dementia.

Neurology. Genetics

Adrienne Henderson-Smith, Jason J Corneveaux, Matthew De Both, Lori Cuyugan, Winnie S Liang, Matthew Huentelman, Charles Adler, Erika Driver-Dunckley, Thomas G Beach, Travis L Dunckley

Affiliations

  1. Neurogenomics Division (A.H.-S., J.J.C., M.D.B., L.C., W.S.L., M.H., T.L.D.), Collaborative Sequencing Center (L.C., W.S.L.), Translational Genomics Research Institute, Phoenix; Division of Neurology (C.A., E.D.-D.), Mayo Clinic, Scottsdale; Banner Sun Health Research Institute (T.G.B.), Sun City, AZ.

PMID: 27275011 PMCID: PMC4881621 DOI: 10.1212/NXG.0000000000000075

Abstract

OBJECTIVE: We sought to determine the underlying cortical gene expression changes associated with Parkinson dementia using a next-generation RNA sequencing approach.

METHODS: In this study, we used RNA sequencing to evaluate differential gene expression and alternative splicing in the posterior cingulate cortex from neurologically normal control patients, patients with Parkinson disease, and patients with Parkinson disease with dementia.

RESULTS: Genes overexpressed in both disease states were involved with an immune response, whereas shared underexpressed genes functioned in signal transduction or as components of the cytoskeleton. Alternative splicing analysis produced a pattern of immune and RNA-processing disturbances.

CONCLUSIONS: Genes with the greatest degree of differential expression did not overlap with genes exhibiting significant alternative splicing activity. Such variation indicates the importance of broadening expression studies to include exon-level changes because there can be significant differential splicing activity with potential structural consequences, a subtlety that is not detected when examining differential gene expression alone, or is underrepresented with probe-limited array technology.

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