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Moaty MI, Fouad S, El Shebini SM, et al. Serum Ceramide Kinase as a Biomarker of Cognitive Functions, and the Effect of Using Two Slimming Dietary Therapies in Obese Middle Aged Females. Open Access Maced J Med Sci. 2015;3(1):18-25doi: 10.3889/oamjms.2015.030.
Moaty, M. I., Fouad, S., El Shebini, S. M., Kazem, Y. M., Ahmed, N. H., Mohamed, M. S., Hussein, A. M., Arafa, A. M., Hanna, L. M., & Tapozada, S. T. (2015). Serum Ceramide Kinase as a Biomarker of Cognitive Functions, and the Effect of Using Two Slimming Dietary Therapies in Obese Middle Aged Females. Open access Macedonian journal of medical sciences, 3(1), 18-25. https://doi.org/10.3889/oamjms.2015.030
Moaty, Maha I A, et al. "Serum Ceramide Kinase as a Biomarker of Cognitive Functions, and the Effect of Using Two Slimming Dietary Therapies in Obese Middle Aged Females." Open access Macedonian journal of medical sciences vol. 3,1 (2015): 18-25. doi: https://doi.org/10.3889/oamjms.2015.030
Moaty MI, Fouad S, El Shebini SM, Kazem YM, Ahmed NH, Mohamed MS, Hussein AM, Arafa AM, Hanna LM, Tapozada ST. Serum Ceramide Kinase as a Biomarker of Cognitive Functions, and the Effect of Using Two Slimming Dietary Therapies in Obese Middle Aged Females. Open Access Maced J Med Sci. 2015 Mar 15;3(1):18-25. doi: 10.3889/oamjms.2015.030. Epub 2015 Feb 26. PMID: 27275191; PMCID: PMC4877781.
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Open Access Maced J Med Sci. 2015 Mar 15;3(1):18-25. doi: 10.3889/oamjms.2015.030. Epub 2015 Feb 26.

Serum Ceramide Kinase as a Biomarker of Cognitive Functions, and the Effect of Using Two Slimming Dietary Therapies in Obese Middle Aged Females.

Open access Macedonian journal of medical sciences

Maha I A Moaty, Suzanne Fouad, Salwa M El Shebini, Yusr M I Kazem, Nihad H Ahmed, Magda S Mohamed, Ahmed M S Hussein, Atiat M Arafa, Laila M Hanna, Salwa T Tapozada

Affiliations

  1. Nutrition and Food Science Department, National Research Centre, Dokki, Giza, Egypt.
  2. Food Technology Department, National Research Centre, Dokki, Giza, Egypt (Affiliation ID: 60014618).

PMID: 27275191 PMCID: PMC4877781 DOI: 10.3889/oamjms.2015.030

Abstract

AIM: Highlighting the impact of obesity on mental and cognitive functions using serum ceramide kinase enzyme concentration as a biomarker for cognitive evaluation in the middle aged females, and also targeting to control the obesity and simultaneously postponing the deterioration of the cognitive functions, by implementing two slimming dietary therapies each incorporating different functional ingredients known to boost cognition.

SUBJECTS AND METHODS: Ninety six obese middle aged females, divided into two groups volunteered to follow a low caloric balanced diet combined with two bread supplements composed essentially of barley flour and wheat germ mixed with either 5% turmeric, group (A); or with 5% ginger, group (B) for 4 weeks, phase (1); to be followed by the hypocaloric diet alone for another 4 weeks, phase (2).

RESULTS: By the end of phase (1), the biochemical analysis showed a positive response of the levels of C-peptide and modified homeostatic model assessment of insulin resistance; also increased levels of the serum ceramide kinase enzyme, coupled with improved cognitive functions tests. Improvement of the relevant metabolic profile, fasting blood glucose, blood pressure and the anthropometric measurements was detected.

CONCLUSION: Using dietary therapy supported by special formulas which contain active ingredients succeeded in reducing weight and improving both the metabolic profile and the cognitive functions.

Keywords: Cognitive function; ceramide kinase enzyme; dietary therapy; middle aged females; obesity

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