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Bulut M, Dönmez BÖ, Öztürk N, et al. Effect of sodium tungstate on visual evoked potentials in diabetic rats. Int J Ophthalmol. 2016;9(5):677-81doi: 10.18240/ijo.2016.05.06.
Bulut, M., Dönmez, B. �. �., Öztürk, N., Başaranlar, G., Kencebay Manas, C., Derin, N., & Özdemir, S. (2016). Effect of sodium tungstate on visual evoked potentials in diabetic rats. International journal of ophthalmology, 9(5), 677-81. https://doi.org/10.18240/ijo.2016.05.06
Bulut, Mehmet, et al. "Effect of sodium tungstate on visual evoked potentials in diabetic rats." International journal of ophthalmology vol. 9,5 (2016): 677-81. doi: https://doi.org/10.18240/ijo.2016.05.06
Bulut M, Dönmez BÖ, Öztürk N, Başaranlar G, Kencebay Manas C, Derin N, Özdemir S. Effect of sodium tungstate on visual evoked potentials in diabetic rats. Int J Ophthalmol. 2016 May 18;9(5):677-81. doi: 10.18240/ijo.2016.05.06. eCollection 2016. PMID: 27275420; PMCID: PMC4886879.
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Int J Ophthalmol. 2016 May 18;9(5):677-81. doi: 10.18240/ijo.2016.05.06. eCollection 2016.

Effect of sodium tungstate on visual evoked potentials in diabetic rats.

International journal of ophthalmology

Mehmet Bulut, Barış Özgür Dönmez, Nihal Öztürk, Göksun Başaranlar, Ceren Kencebay Manas, Narin Derin, Semir Özdemir

Affiliations

  1. Department of Ophthalmology, Antalya Education and Research Hospital, Antalya 07070, Turkey.
  2. Department of Nutrition and Dietetics, School of Health, Akdeniz University, Antalya 07070, Turkey.
  3. Department of Biophysics, Faculty of Medicine, Akdeniz University, Antalya 07070, Turkey.

PMID: 27275420 PMCID: PMC4886879 DOI: 10.18240/ijo.2016.05.06

Abstract

AIM: To evaluate the effect of sodium tungstate on visual evoked potentials (VEPs) in diabetic rats.

METHODS: Wistar rats were randomly divided into three groups as normal control, diabetic control and diabetic rats treated with sodium tungstate. Diabetes was induced by single intraperitoneal injection of streptozotocin (50 mg/kg). Sodium tungstate [40 mg/(kg·d)] was administered for 12wk and then VEPs were recorded. Additionally, thiobarbituric acid reactive substance (TBARS) levels were measured in brain tissues.

RESULTS: The latencies of P1, N1, P2, N2 and P3 waves were significantly prolonged in diabetic rats compared with control group. Diabetes mellitus caused an increase in the lipid peroxidation process that was accompanied by changes in VEPs. However, prolonged latencies of VEPs for all components returned to control levels in sodium tungstate-treated group. The treatment of sodium tungstate significantly decreased brain TBARS levels and depleted the prolonged latencies of VEP components compared with diabetic control group.

CONCLUSION: Sodium tungstate shows protective effects on visual pathway in diabetic rats, and it can be worthy of further study for potential use.

Keywords: diabetes; lipid peroxidation; retinopathy; sodium tungstate; visual evoked potentials

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