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Othman BA, Greenwood C, Abuelela AF, et al. Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Adv Healthc Mater. 2016;5(11):1248doi: 10.1002/adhm.201670053.
Othman, B. A., Greenwood, C., Abuelela, A. F., Bharath, A. A., Chen, S., Theodorou, I., Douglas, T., Uchida, M., Ryan, M., Merzaban, J. S., & Porter, A. E. (2016). Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Advanced healthcare materials, 5(11), 1248. https://doi.org/10.1002/adhm.201670053
Othman, Basmah A, et al. "Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016)." Advanced healthcare materials vol. 5,11 (2016): 1248. doi: https://doi.org/10.1002/adhm.201670053
Othman BA, Greenwood C, Abuelela AF, Bharath AA, Chen S, Theodorou I, Douglas T, Uchida M, Ryan M, Merzaban JS, Porter AE. Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016). Adv Healthc Mater. 2016 Jun;5(11):1248. doi: 10.1002/adhm.201670053. PMID: 27275627.
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Adv Healthc Mater. 2016 Jun;5(11):1248. doi: 10.1002/adhm.201670053.

Targeted Cancer Therapy: Correlative Light-Electron Microscopy Shows RGD-Targeted ZnO Nanoparticles Dissolve in the Intracellular Environment of Triple Negative Breast Cancer Cells and Cause Apoptosis with Intratumor Heterogeneity (Adv. Healthcare Mater. 11/2016).

Advanced healthcare materials

Basmah A Othman, Christina Greenwood, Ayman F Abuelela, Anil A Bharath, Shu Chen, Ioannis Theodorou, Trevor Douglas, Maskai Uchida, Mary Ryan, Jasmeen S Merzaban, Alexandra E Porter

Affiliations

  1. Department of Materials, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.
  2. Cell and Molecular Biology Research Laboratory, Faculty of Medical Sciences, Post Graduate Medical Institute, Anglia Ruskin University, Bishop Hall Lane, Chelmsford, CM1 1SQ, UK.
  3. Cell Migration and Signaling Laboratory, Division of Biological and Environmental Sciences and Engineering, King Abdullah University of Science and Engineering (KAUST), Thuwal, 23955-6900, Saudi Arabia.
  4. Department of Bioengineering, Imperial College London, Royal School of Mines, Exhibition Road, London, SW7 2AZ, UK.
  5. Department of Chemistry, Indiana University, 800 E. Kirkwood Avenue, Bloomington, IN, 47405, USA.
  6. Imperial College London and London Centre for Nanotechnology, London, SW7 2AZ, UK.

PMID: 27275627 DOI: 10.1002/adhm.201670053

Abstract

On page 1310 J. S. Merzaban, A. E. Porter, and co-workers present fluorescently labeled RGD-targeted ZnO nanoparticles (NPs; green) for the targeted delivery of cytotoxic ZnO to integrin αvβ3 receptors expressed on triple negative breast cancer cells. Correlative light-electron microscopy shows that NPs dissolve into ionic Zn(2+) (blue) upon uptake and cause apoptosis (red) with intra-tumor heterogeneity, thereby providing a possible strategy for targeted breast cancer therapy. Cover design by Ivan Gromicho.

© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords: cellular targeting; cytotoxicity; integrin αvβ3 receptors; triple negative breast cancer cells; zinc oxide nanoparticles

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