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Tang Y, Benusiglio D, Grinevich V, et al. Distinct Types of Feeding Related Neurons in Mouse Hypothalamus. Front Behav Neurosci. 2016;10:91doi: 10.3389/fnbeh.2016.00091.
Tang, Y., Benusiglio, D., Grinevich, V., & Lin, L. (2016). Distinct Types of Feeding Related Neurons in Mouse Hypothalamus. Frontiers in behavioral neuroscience, 1091. https://doi.org/10.3389/fnbeh.2016.00091
Tang, Yan, et al. "Distinct Types of Feeding Related Neurons in Mouse Hypothalamus." Frontiers in behavioral neuroscience vol. 10 (2016): 91. doi: https://doi.org/10.3389/fnbeh.2016.00091
Tang Y, Benusiglio D, Grinevich V, Lin L. Distinct Types of Feeding Related Neurons in Mouse Hypothalamus. Front Behav Neurosci. 2016 May 18;10:91. doi: 10.3389/fnbeh.2016.00091. eCollection 2016. PMID: 27242460; PMCID: PMC4870269.
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Front Behav Neurosci. 2016 May 18;10:91. doi: 10.3389/fnbeh.2016.00091. eCollection 2016.

Distinct Types of Feeding Related Neurons in Mouse Hypothalamus.

Frontiers in behavioral neuroscience

Yan Tang, Diego Benusiglio, Valery Grinevich, Longnian Lin

Affiliations

  1. Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science and the Collaborative Innovation Center for Brain Science, Institute of Brain Functional Genomics, East China Normal UniversityShanghai, China; Schaller Research Group on Neuropeptides at German Cancer Research Center, Central Institute of Mental Health, and Cell Networks Cluster of Excellence at the University of HeidelbergHeidelberg, Germany.
  2. Schaller Research Group on Neuropeptides at German Cancer Research Center, Central Institute of Mental Health, and Cell Networks Cluster of Excellence at the University of Heidelberg Heidelberg, Germany.
  3. Key Laboratory of Brain Functional Genomics (Ministry of Education and Shanghai), School of Life Science and the Collaborative Innovation Center for Brain Science, Institute of Brain Functional Genomics, East China Normal University Shanghai, China.

PMID: 27242460 PMCID: PMC4870269 DOI: 10.3389/fnbeh.2016.00091

Abstract

The last two decades of research provided evidence for a substantial heterogeneity among feeding-related neurons (FRNs) in the hypothalamus. However, it remains unclear how FRNs differ in their firing patterns during food intake. Here, we investigated the relationship between the activity of neurons in mouse hypothalamus and their feeding behavior. Using tetrode-based in vivo recording technique, we identified various firing patterns of hypothalamic FRNs, which, after the initiation of food intake, can be sorted into four types: sharp increase (type I), slow increase (type II), sharp decrease (type III), and sustained decrease (type IV) of firing rates. The feeding-related firing response of FRNs was rigidly related to the duration of food intake and, to a less extent, associated with the type of food. The majority of these FRNs responded to glucose and leptin and exhibited electrophysiological characteristics of putative GABAergic neurons. In conclusion, our study demonstrated the diversity of neurons in the complex hypothalamic network coordinating food intake.

Keywords: feeding behavior; feeding-related neurons; firing patterns; food intake; hypothalamus; in vivo recording

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