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Hatipoğlu F, Karapolat İ, Ömür Ö, et al. Recurrence Incidence in Differentiated Thyroid Cancers and the Importance of Diagnostic Iodine-131 Scintigraphy in Clinical Follow-up. Mol Imaging Radionucl Ther. 2016;25(2):85-90doi: 10.4274/mirt.35220.
Hatipoğlu, F., Karapolat, �. �., Ömür, �. �., Akgün, A., Yanarateş, A., & Kumanlıoğlu, K. (2016). Recurrence Incidence in Differentiated Thyroid Cancers and the Importance of Diagnostic Iodine-131 Scintigraphy in Clinical Follow-up. Molecular imaging and radionuclide therapy, 25(2), 85-90. https://doi.org/10.4274/mirt.35220
Hatipoğlu, Filiz, et al. "Recurrence Incidence in Differentiated Thyroid Cancers and the Importance of Diagnostic Iodine-131 Scintigraphy in Clinical Follow-up." Molecular imaging and radionuclide therapy vol. 25,2 (2016): 85-90. doi: https://doi.org/10.4274/mirt.35220
Hatipoğlu F, Karapolat İ, Ömür Ö, Akgün A, Yanarateş A, Kumanlıoğlu K. Recurrence Incidence in Differentiated Thyroid Cancers and the Importance of Diagnostic Iodine-131 Scintigraphy in Clinical Follow-up. Mol Imaging Radionucl Ther. 2016 Jun 05;25(2):85-90. doi: 10.4274/mirt.35220. PMID: 27277325; PMCID: PMC5096625.
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Mol Imaging Radionucl Ther. 2016 Jun 05;25(2):85-90. doi: 10.4274/mirt.35220.

Recurrence Incidence in Differentiated Thyroid Cancers and the Importance of Diagnostic Iodine-131 Scintigraphy in Clinical Follow-up.

Molecular imaging and radionuclide therapy

Filiz Hatipoğlu, İnanç Karapolat, Özgür Ömür, Ayşegül Akgün, Ahmet Yanarateş, Kamil Kumanlıoğlu

Affiliations

  1. ?ifa University Faculty of Medicine, Department of Nuclear Medicine, ?zmir, Turkey, Phone: +90 533 378 53 37 E-mail: [email protected].

PMID: 27277325 PMCID: PMC5096625 DOI: 10.4274/mirt.35220

Abstract

OBJECTIVE: Differentiated thyroid cancers (DTC) are tumors with good prognosis. However, local recurrence or distant metastasis can be observed. In our study, we aimed to investigate the incidence of recurrence and the importance of diagnostic iodine-131 whole body scan (WBS) in clinical follow-up in patients with DTC.

METHODS: The clinical data of 217 patients with DTC who were followed-up more than 3 years were reviewed retrospectively. The incidence of recurrence was investigated in a group of patients who had radioactive iodine (RAI) treatment and showed no sign of residual thyroid tissue or metastasis with diagnostic WBS that was performed at 6-12 months after therapy and had a thyroglobulin (Tg) level lower than 2 ng/dl.

RESULTS: At the time of diagnosis, ten cases had thyroid capsule invasion, 25 cases had extra-thyroid soft tissue invasion, 11 patients showed lymph node metastasis and four patients had distant organ metastasis. One hundred forty-five patients had RAI treatment at ablation dose (75-100 mCi), whereas 35 patients had RAI treatment at metastasis dose (150-200 mCi). Thirty-seven patients with papillary microcarcinoma did not receive RAI treatment. In 12 (%7.5) of the 160 patients who were considered as "successful ablation", a recurrence was identified. Recurrence was detected by diagnostic WBS in all cases and stimulated Tg level was <2 ng/dL with the exception of the two cases who had distant metastasis.

CONCLUSION: Identification of pathological findings with WBS in patients who developed local recurrence in the absence of elevated Tg highlights the importance of diagnostic WBS in clinical follow-up.

Conflict of interest statement

No conflict of interest was declared by the authors.

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