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Vanner S, Greenwood-Van Meerveld B, Mawe G, et al. Fundamentals of Neurogastroenterology: Basic Science. Gastroenterology. 2016;doi: 10.1053/j.gastro.2016.02.018.
Vanner, S., Greenwood-Van Meerveld, B., Mawe, G., Shea-Donohue, T., Verdu, E. F., Wood, J., & Grundy, D. (2016). Fundamentals of Neurogastroenterology: Basic Science. Gastroenterology, . https://doi.org/10.1053/j.gastro.2016.02.018
Vanner, Stephen, et al. "Fundamentals of Neurogastroenterology: Basic Science." Gastroenterology vol. (2016). doi: https://doi.org/10.1053/j.gastro.2016.02.018
Vanner S, Greenwood-Van Meerveld B, Mawe G, Shea-Donohue T, Verdu EF, Wood J, Grundy D. Fundamentals of Neurogastroenterology: Basic Science. Gastroenterology. 2016 Feb 18; doi: 10.1053/j.gastro.2016.02.018. Epub 2016 Feb 18. PMID: 27144618; PMCID: PMC5673591.
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Gastroenterology. 2016 Feb 18; doi: 10.1053/j.gastro.2016.02.018. Epub 2016 Feb 18.

Fundamentals of Neurogastroenterology: Basic Science.

Gastroenterology

Stephen Vanner, Beverley Greenwood-Van Meerveld, Gary Mawe, Terez Shea-Donohue, Elena F Verdu, Jackie Wood, David Grundy

Affiliations

  1. Gastrointestinal Diseases Research Unit, Kingston General Hospital, Kingston, Ontario, Canada. Electronic address: [email protected].
  2. Oklahoma Center for Neuroscience, Department of Physiology, VA Medical Center, University of Oklahoma, Health Sciences Center, Oklahoma City, Oklahoma.
  3. Department of Neurological Sciences, Pharmacology and Medicine Division, Gastroenterology and Hepatology, University of Vermont, Burlington, Vermont.
  4. Department of Medicine and Physiology, University of Maryland, School of Medicine, Baltimore, Maryland.
  5. Farncombe Family Digestive Health Research Institute, McMaster University, Health Sciences Center, Hamilton, Ontario, Canada.
  6. Department of Physiology and Cell Biology, The Ohio State University, Columbus, Ohio.
  7. Department of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.

PMID: 27144618 PMCID: PMC5673591 DOI: 10.1053/j.gastro.2016.02.018

Abstract

This review examines the fundamentals of neurogastroenterology that may underlie the pathophysiology of functional GI disorders (FGIDs). It was prepared by an invited committee of international experts and represents an abbreviated version of their consensus document that will be published in its entirety in the forthcoming book and online version entitled ROME IV. It emphasizes recent advances in our understanding of the enteric nervous system, sensory physiology underlying pain, and stress signaling pathways. There is also a focus on neuroimmmune signaling and intestinal barrier function, given the recent evidence implicating the microbiome, diet, and mucosal immune activation in FGIDs. Together, these advances provide a host of exciting new targets to identify and treat FGIDs and new areas for future research into their pathophysiology.

Copyright © 2016 AGA Institute. Published by Elsevier Inc. All rights reserved.

Keywords: enteric nervous system; mucosal barrier function; neuroimmune signaling; sensory physiology

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