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Niki K, Sugawara M, Chang D, et al. Effects of sublingual nitroglycerin on working conditions of the heart and arterial system: analysis using wave intensity. J Med Ultrason (2001). 2005;32(4):145-52doi: 10.1007/s10396-005-0057-8.
Niki, K., Sugawara, M., Chang, D., Harada, A., Okada, T., & Tanaka, R. (2005). Effects of sublingual nitroglycerin on working conditions of the heart and arterial system: analysis using wave intensity. Journal of medical ultrasonics (2001), 32(4), 145-52. https://doi.org/10.1007/s10396-005-0057-8
Niki, Kiyomi, et al. "Effects of sublingual nitroglycerin on working conditions of the heart and arterial system: analysis using wave intensity." Journal of medical ultrasonics (2001) vol. 32,4 (2005): 145-52. doi: https://doi.org/10.1007/s10396-005-0057-8
Niki K, Sugawara M, Chang D, Harada A, Okada T, Tanaka R. Effects of sublingual nitroglycerin on working conditions of the heart and arterial system: analysis using wave intensity. J Med Ultrason (2001). 2005 Dec;32(4):145-52. doi: 10.1007/s10396-005-0057-8. PMID: 27277481.
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J Med Ultrason (2001). 2005 Dec;32(4):145-52. doi: 10.1007/s10396-005-0057-8.

Effects of sublingual nitroglycerin on working conditions of the heart and arterial system: analysis using wave intensity.

Journal of medical ultrasonics (2001)

Kiyomi Niki, Motoaki Sugawara, Dehua Chang, Akimitsu Harada, Takashi Okada, Rie Tanaka

Affiliations

  1. Department of Cardiovascular Sciences, The Heart Institute of Japan, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan. [email protected].
  2. Department of Cardiovascular Sciences, The Heart Institute of Japan, Tokyo Women's Medical University School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.
  3. Research Laboratory, Aloka Co. Ltd, Tokyo, Japan.
  4. Nihon Kohden Corp., Tokyo, Japan.

PMID: 27277481 DOI: 10.1007/s10396-005-0057-8

Abstract

PURPOSE: The effects of nitroglycerin (NTG) on the vascular system are well known. However, the effects of NTG on the heart are still obscure, because these effects are modified by those on the vascular system, and vice versa. Therefore, to evaluate the hemodynamic effects of NTG, it is important to understand the interaction between the heart and the vascular system. Wave intensity (WI) is a new hemodynamic index that provides information about working conditions of the heart interacting with the arterial system. The purpose of this study was to evaluate the interactive effects of NTG on the cardiovascular system in normal subjects using wave intensity.

METHODS: We simultaneously measured carotid arterial blood flow velocity and diameter change using a specially designed ultrasonic system, and calculated the WI and the stiffness parameter β. Measurements were made in 13 normal subjects (9 men and 4 women, aged 47 ± 10 years) in the supine position before and after sublingual NTG.

RESULTS: The maximum value of WI (W 1) and the mid-systolic expansion wave (X) increased (W 1 from 9.1 ± 4.3 to 12.3 ± 5.5 × 10(3) mmHg m/s(3), P < 0.001; X from 105 ± 185 to 345 ± 370 mmHg m/s(3), P < 0.05). β increased (from 10.5 ± 3.8 to 14.1 ± 3.8, P < 0.001). The pressure contours changed considerably.

CONCLUSIONS: NTG increased W 1 and the mid-systolic expansion wave, which suggests enhanced cardiac power during the initial ejection and mid-systolic unloading. These results are new findings about the effects of NTG that can be added to the widely known late systolic unloading and preload reduction. NTG also increased arterial stiffness, which reduces the Windkessel function. By using an echo-Doppler system, WI can be obtained noninvasively. WI has the clinical potential to provide quantitative and detailed information about working conditions of the heart interacting with the arterial system.

Keywords: color Doppler; echo tracking; expansion wave; nitroglycerin; wave intensity

References

  1. Heart Vessels. 2002 Dec;17(2):61-8 - PubMed
  2. Biorheology. 1980;17(3):211-8 - PubMed
  3. Hypertension. 1995 Sep;26(3):520-3 - PubMed
  4. Heart Vessels. 2002 Nov;17 (1):12-21 - PubMed
  5. J Appl Physiol. 1961 May;16:545-8 - PubMed
  6. Heart Vessels. 1997;Suppl 12:128-34 - PubMed
  7. J Biomech Eng. 1990 Aug;112(3):322-6 - PubMed
  8. Heart Vessels. 2000;15(1):49-51 - PubMed
  9. Cardiovasc Res. 1988 Jul;22(7):494-500 - PubMed
  10. Eur Heart J. 1990 Feb;11(2):138-44 - PubMed
  11. Heart Vessels. 1999;14 (6):263-71 - PubMed
  12. J Am Soc Echocardiogr. 2000 Dec;13(12 ):1100-8 - PubMed
  13. Heart Vessels. 2003 Jul;18(3):107-11 - PubMed
  14. J Hypertens. 1993 Apr;11(4):327-37 - PubMed
  15. Circulation. 1997 Oct 21;96(8):2675-82 - PubMed
  16. Am J Cardiol. 1992 Sep 24;70(8):82B-87B - PubMed
  17. J Appl Physiol. 1963 Nov;18:1111-7 - PubMed
  18. Heart Vessels. 2002 Mar;16(3):91-8 - PubMed
  19. Circulation. 1980 Jul;62(1):105-16 - PubMed
  20. J Am Soc Echocardiogr. 1999 Dec;12 (12 ):1065-72 - PubMed
  21. Heart Vessels. 1988;4(4):241-5 - PubMed
  22. Pflugers Arch. 1971;324(2):124-33 - PubMed
  23. Hypertension. 2001 Dec 1;38(6):1433-9 - PubMed
  24. Cardiovasc Res. 1986 Feb;20(2):153-60 - PubMed
  25. Cardiovasc Res. 1997 Feb;33(2):433-46 - PubMed

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