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Shen WJ, Azhar S, Kraemer FB. ACTH Regulation of Adrenal SR-B1. Front Endocrinol (Lausanne). 2016;7:42doi: 10.3389/fendo.2016.00042.
Shen, W. J., Azhar, S., & Kraemer, F. B. (2016). ACTH Regulation of Adrenal SR-B1. Frontiers in endocrinology, 742. https://doi.org/10.3389/fendo.2016.00042
Shen, Wen-Jun, et al. "ACTH Regulation of Adrenal SR-B1." Frontiers in endocrinology vol. 7 (2016): 42. doi: https://doi.org/10.3389/fendo.2016.00042
Shen WJ, Azhar S, Kraemer FB. ACTH Regulation of Adrenal SR-B1. Front Endocrinol (Lausanne). 2016 May 13;7:42. doi: 10.3389/fendo.2016.00042. eCollection 2016. PMID: 27242666; PMCID: PMC4865504.
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Front Endocrinol (Lausanne). 2016 May 13;7:42. doi: 10.3389/fendo.2016.00042. eCollection 2016.

ACTH Regulation of Adrenal SR-B1.

Frontiers in endocrinology

Wen-Jun Shen, Salman Azhar, Fredric B Kraemer

Affiliations

  1. The Division of Endocrinology, Stanford University, Stanford, CA, USA; Geriatric Research, Education and Clinical Center, Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA.

PMID: 27242666 PMCID: PMC4865504 DOI: 10.3389/fendo.2016.00042

Abstract

The adrenal gland is one of the prominent sites for steroid hormone synthesis. Lipoprotein-derived cholesterol esters (CEs) delivered via SR-B1 constitute the dominant source of cholesterol for steroidogenesis, particularly in rodents. Adrenocorticotropic hormone (ACTH) stimulates steroidogenesis through downstream actions on multiple components involved in steroidogenesis. Both acute and chronic ACTH treatments can modulate SR-B1 function, including its transcription, posttranscriptional stability, phosphorylation and dimerization status, as well as the interaction with other protein partners, all of which result in changes in the ability of SR-B1 to mediate HDL-CE uptake and the supply of cholesterol for conversion to steroids. Here, we provide a review of the recent findings on the regulation of adrenal SR-B1 function by ACTH.

Keywords: ACTH; SR-B1; adrenal; cholesterol

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