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Ye C, Driver JP. Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells. Front Immunol. 2016;7:169doi: 10.3389/fimmu.2016.00169.
Ye, C., & Driver, J. P. (2016). Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells. Frontiers in immunology, 7169. https://doi.org/10.3389/fimmu.2016.00169
Ye, Cheng, and Driver, John P. "Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells." Frontiers in immunology vol. 7 (2016): 169. doi: https://doi.org/10.3389/fimmu.2016.00169
Ye C, Driver JP. Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells. Front Immunol. 2016 May 09;7:169. doi: 10.3389/fimmu.2016.00169. eCollection 2016. PMID: 27242781; PMCID: PMC4860527.
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Front Immunol. 2016 May 09;7:169. doi: 10.3389/fimmu.2016.00169. eCollection 2016.

Suppressors of Cytokine Signaling in Sickness and in Health of Pancreatic β-Cells.

Frontiers in immunology

Cheng Ye, John P Driver

Affiliations

  1. Department of Animal Sciences, University of Florida , Gainesville, FL , USA.

PMID: 27242781 PMCID: PMC4860527 DOI: 10.3389/fimmu.2016.00169

Abstract

Suppressors of cytokine signaling (SOCS) are a family of eight proteins that negatively regulate Janus kinase and signal transducers and activators of transcription signaling in cells that utilize this pathway to respond to extracellular stimuli. SOCS are best known for attenuating cytokine signaling in the immune system. However, they are also expressed in many other cell types, including pancreatic β-cells, where there is considerable interest in harnessing SOCS molecules to prevent cytokine-mediated apoptosis during diabetes and allogeneic transplantation. Apart from their potential as therapeutic targets, SOCS molecules play a central role for regulating important functions in β-cells, including growth, glucose sensing, and insulin secretion. This review will discuss SOCS proteins as central regulators for diverse cellular processes important for normal β-cell function as well as their protective anti-apoptotic effects during β-cell stress.

Keywords: SOCS expression; diabetes; inflammatory cytokines; insulin signaling; suppressors of cytokine signaling; β-cell growth; β-cells

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