Display options
Cite
Kuriakose SM, Singh R, Uzonna JE. Host Intracellular Signaling Events and Pro-inflammatory Cytokine Production in African Trypanosomiasis. Front Immunol. 2016;7:181doi: 10.3389/fimmu.2016.00181.
Kuriakose, S. M., Singh, R., & Uzonna, J. E. (2016). Host Intracellular Signaling Events and Pro-inflammatory Cytokine Production in African Trypanosomiasis. Frontiers in immunology, 7181. https://doi.org/10.3389/fimmu.2016.00181
Kuriakose, Shiby M, et al. "Host Intracellular Signaling Events and Pro-inflammatory Cytokine Production in African Trypanosomiasis." Frontiers in immunology vol. 7 (2016): 181. doi: https://doi.org/10.3389/fimmu.2016.00181
Kuriakose SM, Singh R, Uzonna JE. Host Intracellular Signaling Events and Pro-inflammatory Cytokine Production in African Trypanosomiasis. Front Immunol. 2016 May 19;7:181. doi: 10.3389/fimmu.2016.00181. eCollection 2016. PMID: 27242788; PMCID: PMC4872169.
Copy Download .nbib Format: NLM
Share it on

Front Immunol. 2016 May 19;7:181. doi: 10.3389/fimmu.2016.00181. eCollection 2016.

Host Intracellular Signaling Events and Pro-inflammatory Cytokine Production in African Trypanosomiasis.

Frontiers in immunology

Shiby M Kuriakose, Rani Singh, Jude E Uzonna

Affiliations

  1. Department of Immunology, Faculty of Health Sciences, University of Manitoba , Winnipeg, MB , Canada.

PMID: 27242788 PMCID: PMC4872169 DOI: 10.3389/fimmu.2016.00181

Abstract

Pathogens, such as bacteria, viruses, and parasites, possess specific molecules or proteins that are recognized by several host innate immune receptors, leading to the activation of several intracellular signaling molecules and pathways. The magnitude and quality of these events significantly affect the outcome of infection. African trypanosomes, including Trypanosoma congolense, are capable of manipulating the host immune response, including the activity of macrophages, which are the key immune cells that contribute to the immunopathogenesis of African trypanosomiasis. Although it is known that immune hyperactivation and excessive pro-inflammatory cytokine production are the hallmarks of African trypanosomiasis, the mechanisms through which these events are triggered are poorly defined. However, it is known that macrophages may play a significant role in these processes, because phagocytosis of trypanosomes by macrophages initiates intracellular signal transduction cascades that lead to the release of pro-inflammatory cytokines and alteration in cell function. This review highlights recent progress in our understanding of the innate immune receptors, signaling pathways, and transcription factors involved in T. congolense-induced pro-inflammatory cytokine production in macrophages. It will reveal the existence of complex signaling events through which the parasite modulates the host immune response, thus identifying novel targets that could aid in designing strategies to effectively control the disease.

Keywords: African trypanosomiasis; host–parasite interactions; innate immune response; intracellular signaling peptides and proteins; pro-inflammatory cytokines

References

  1. J Leukoc Biol. 2006 Dec;80(6):1298-307 - PubMed
  2. Parasite. 2003 Mar;10(1):59-64 - PubMed
  3. PLoS One. 2013;8(3):e59631 - PubMed
  4. Infect Immun. 2014 Mar;82(3):1074-83 - PubMed
  5. F1000Prime Rep. 2014 Mar 03;6:13 - PubMed
  6. Nat Med. 2006 Aug;12(8):955-60 - PubMed
  7. Nature. 2003 Mar 6;422(6927):83-7 - PubMed
  8. J Immunol. 2004 Jun 1;172(11):6954-60 - PubMed
  9. Parasite Immunol. 2007 Dec;29(12):609-19 - PubMed
  10. Eur J Immunol. 1991 Oct;21(10):2447-54 - PubMed
  11. Infect Immun. 1999 Jun;67(6):3128-32 - PubMed
  12. J Immunol. 2001 Mar 1;166(5):3423-31 - PubMed
  13. Am J Trop Med Hyg. 1995 Nov;53(5):539-43 - PubMed
  14. J Immunol. 1998 Nov 15;161(10):5507-15 - PubMed
  15. Science. 1994 Jun 3;264(5164):1415-21 - PubMed
  16. J Immunol. 1998 Dec 15;161(12):6775-83 - PubMed
  17. Nat Rev Immunol. 2001 Nov;1(2):135-45 - PubMed
  18. Semin Cancer Biol. 1997 Apr;8(2):63-73 - PubMed
  19. Res Vet Sci. 1992 May;52(3):292-8 - PubMed
  20. J Immunol. 2007 Jul 1;179(1):548-56 - PubMed
  21. Trop Anim Health Prod. 1972;4(1):14-22 - PubMed
  22. Immunity. 2011 May 27;34(5):637-50 - PubMed
  23. J Immunol. 2004 Feb 1;172(3):1711-8 - PubMed
  24. Bull World Health Organ. 1963;28(5-6):595-613 - PubMed
  25. Lancet Infect Dis. 2003 Dec;3(12):804-8 - PubMed
  26. Trends Parasitol. 2010 Sep;26(9):457-64 - PubMed
  27. Genes Dev. 2006 Dec 15;20(24):3372-81 - PubMed
  28. J Travel Med. 2012 Jan-Feb;19(1):44-53 - PubMed
  29. Exp Parasitol. 1992 Nov;75(3):353-60 - PubMed
  30. Parasite Immunol. 1998 Jun;20(6):293-302 - PubMed
  31. J Interferon Cytokine Res. 1999 Jan;19(1):59-65 - PubMed
  32. Parasite Immunol. 1999 Feb;21(2):57-71 - PubMed
  33. N Engl J Med. 2006 Dec 28;355(26):2752-6 - PubMed
  34. Physiol Genomics. 2006 Dec 13;28(1):53-61 - PubMed
  35. J Immunol. 2005 Aug 15;175(4):2501-9 - PubMed
  36. Malar J. 2011 Mar 28;10:69 - PubMed
  37. J Infect Dis. 2012 Jan 15;205(2):320-32 - PubMed
  38. J Immunol. 1993 Nov 15;151(10):5492-503 - PubMed
  39. J Immunol. 2003 Apr 15;170(8):4237-41 - PubMed
  40. J Infect Dis. 2009 Dec 15;200(12):1849-60 - PubMed
  41. J Immunol. 2006 Sep 15;177(6):3515-9 - PubMed
  42. Cytokine. 2000 Jul;12(7):1024-34 - PubMed
  43. Int Immunol. 2005 Jan;17(1):1-14 - PubMed
  44. Hypertension. 1998 Jan;31(1 Pt 2):152-61 - PubMed
  45. J Protozool. 1992 Jan-Feb;39(1):224-35 - PubMed
  46. Acta Trop. 2003 Mar;85(3):391-404 - PubMed
  47. Infect Immun. 1980 Jun;28(3):824-31 - PubMed
  48. Prog Biophys Mol Biol. 1999;71(3-4):479-500 - PubMed
  49. Science. 2005 Jul 15;309(5733):469-72 - PubMed
  50. Exp Parasitol. 1999 Jun;92(2):131-43 - PubMed
  51. PLoS One. 2012;7(11):e48696 - PubMed
  52. Infect Immun. 1994 May;62(5):2135-7 - PubMed
  53. J Leukoc Biol. 2009 Apr;85(4):664-72 - PubMed
  54. J Immunol. 1983 Jan;130(1):405-11 - PubMed
  55. J Immunol. 2008 Feb 15;180(4):2514-21 - PubMed
  56. Cell. 2006 Feb 24;124(4):783-801 - PubMed
  57. Int Immunol. 2009 Apr;21(4):317-37 - PubMed
  58. J Infect Dis. 2011 May 1;203(9):1256-63 - PubMed
  59. Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62 - PubMed
  60. Mol Biochem Parasitol. 2004 Nov;138(1):9-20 - PubMed
  61. Innate Immun. 2014 Oct;20(7):760-73 - PubMed
  62. Future Microbiol. 2009 Oct;4(8):1075-87 - PubMed
  63. Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13951-6 - PubMed
  64. J Infect Dis. 2001 Jun 15;183(12):1794-800 - PubMed
  65. J Immunol. 2009 Sep 1;183(5):3344-55 - PubMed
  66. PLoS Negl Trop Dis. 2012;6(7):e1761 - PubMed
  67. J Infect Dis. 2006 Jun 1;193(11):1575-83 - PubMed
  68. J Leukoc Biol. 2001 Mar;69(3):387-96 - PubMed
  69. J Cell Sci. 2004 Mar 15;117(Pt 8):1281-3 - PubMed
  70. J Leukoc Biol. 2004 Aug;76(2):399-405 - PubMed
  71. Adv Exp Med Biol. 1977;93:65-73 - PubMed
  72. Trends Parasitol. 2001 Jan;17(1):2-3 - PubMed
  73. Nat Rev Immunol. 2004 Jul;4(7):499-511 - PubMed
  74. J Infect Dis. 2004 Feb 1;189(3):527-39 - PubMed
  75. J Leukoc Biol. 2001 Jan;69(1):3-10 - PubMed
  76. Scand J Immunol. 2012 Jan;75(1):5-15 - PubMed
  77. Cell. 1998 Dec 11;95(6):839-46 - PubMed
  78. PLoS One. 2014 Oct 23;9(10):e110512 - PubMed
  79. J Immunol. 2001 Nov 15;167(10):5928-34 - PubMed
  80. J Leukoc Biol. 2001 May;69(5):685-90 - PubMed
  81. J Immunol. 2006 Feb 1;176(3):1724-32 - PubMed
  82. Exp Parasitol. 1982 Dec;54(3):310-6 - PubMed
  83. J Exp Med. 2000 Dec 4;192(11):1563-76 - PubMed
  84. Parasitology. 2010 Dec;137(14):2051-63 - PubMed
  85. Microbes Infect. 2006 Apr;8(5):1209-18 - PubMed
  86. J Immunol. 2003 Aug 1;171(3):1466-72 - PubMed
  87. J Biol Chem. 2005 Mar 4;280(9):8606-16 - PubMed
  88. Blood. 2009 Feb 12;113(7):1399-407 - PubMed
  89. J Biol Chem. 1992 May 25;267(15):10797-803 - PubMed
  90. J Immunol. 2007 Sep 1;179(5):2748-57 - PubMed
  91. Immunol Rev. 2004 Oct;201:191-205 - PubMed
  92. Infect Immun. 1983 Mar;39(3):1080-6 - PubMed
  93. Eur J Immunol. 2003 Jan;33(1):108-18 - PubMed
  94. J Immunol. 2007 Mar 1;178(5):2623-9 - PubMed

Publication Types