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Wen YL, Kudo M, Minami Y, et al. Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging. J Med Ultrason (2001). 2003;30(3):141-51doi: 10.1007/BF02481219.
Wen, Y. L., Kudo, M., Minami, Y., Chung, H., Suetomi, Y., Onda, H., Kitano, M., Kawasaki, T., & Maekawa, K. (2003). Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging. Journal of medical ultrasonics (2001), 30(3), 141-51. https://doi.org/10.1007/BF02481219
Wen, Yan Ling, et al. "Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging." Journal of medical ultrasonics (2001) vol. 30,3 (2003): 141-51. doi: https://doi.org/10.1007/BF02481219
Wen YL, Kudo M, Minami Y, Chung H, Suetomi Y, Onda H, Kitano M, Kawasaki T, Maekawa K. Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging. J Med Ultrason (2001). 2003 Sep;30(3):141-51. doi: 10.1007/BF02481219. PMID: 27278304.
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J Med Ultrason (2001). 2003 Sep;30(3):141-51. doi: 10.1007/BF02481219.

Detection of tumor vascularity in hepatocellular carcinoma with contrast-enhanced Dynamic Flow imaging: Comparison with contrast-enhanced power Doppler imaging.

Journal of medical ultrasonics (2001)

Yan Ling Wen, Masatoshi Kudo, Yasunori Minami, Hobyung Chung, Yoichiro Suetomi, Hirokazu Onda, Masayuki Kitano, Toshihiko Kawasaki, Kiyoshi Maekawa

Affiliations

  1. Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2, 589-8511, Ohno-higashi, Japan.
  2. Department of Ultrasound, Sun Yut-Sen University of Medical Science Memorial Hospital, 107 Yanjiangxi Road, 510120, Guangzhou, China.
  3. Abdominal Ultrasound Unit, Kinki University School of Medicine, 377-2, 589-8511, Ohno-higashi, Japan.

PMID: 27278304 DOI: 10.1007/BF02481219

Abstract

OBJECTIVE: To compare the effectiveness of contrast-enhanced Dynamic Flow imaging and contrast-enhanced power Doppler imaging using Levovist(®) as a microbubble contrast agent in evaluating intratumoral vascularity in hepatocellular carcinoma (HCC).

MATERIALS AND METHODS: Twenty-nine patients with 54 hepatocellular carcinoma nodules (before treatment, 31; after treatment, 23) were studied with both Dynamic Flow and power Doppler imaging with intravenous injection of Levovist(®). Tumor vascularity was categorized as 0, no blood flow signals within the tumor; 1, dotlike blood flow signals within the tumor; 2, moderate blood flow signals within the tumor; and 3, abundant blood flow signals within the tumor. Detectability of intratumoral vascularity of hepatocellular carcinoma in three groups based on tumor depth, blooming and noise artifacts on contrast-enhanced Dynamic Flow and contrast-enhanced power Doppler imaging were also compared with results obtained using dynamic CT as a the gold standard. The effectiveness of contrast-enhanced Dynamic Flow and contrast-enhanced power Doppler imaging in assessing therapeutic effect were compared at the same time.

RESULTS: The ability of contrast-enhanced Dynamic Flow Doppler imaging to detect tumor vascularity in the superficial and intermediate hepatocellular carcinoma groups was close to that of contrast-enhanced power Doppler imaging (p>0.05). However, contrast-enhanced Dynamic Flow imaging demonstrated tumor parenchymal stain in 28 hepatocellular carcinoma nodules (61%), which was not detected by contrast-enhanced power Doppler imaging. Further, significantly fewer artifacts appeared in contrast-enhanced Dynamic Flow imaging than in contrast-enhanced power Doppler imaging (p<0.001). In assessing therapeutic response, the sensitivity of contrast-enhanced Dynamic Flow imaging was similar to that of dynamic CT. In deep areas, however, those more than 6 cm below the surface of the body, contrast-enhanced Dynamic Flow imaging was less sensitivity than contrast-enhanced power Doppler imaging (p=0.005).

CONCLUSION: Contrast-enhanced Dynamic Flow imaging provides an effective approach to assessing intratumoral vascularity and therapeutic response in HCC lesions situated less than 6 cm from the surface of the body. It is superior to contrast-enhanced power Doppler imaging in its ability to detect tumor parenchymal stain and production of fewer artifacts.

Keywords: contrast medium; hepatocellular carcinoma; liver neoplasm; power Doppler imaging; wide-band Doppler imaging

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