Postepy Dermatol Alergol. 2016 Apr;33(2):120-7. doi: 10.5114/ada.2016.59154. Epub 2016 May 16.
Differentiating of cross-reactions in patients with latex allergy with the use of ISAC test.
Postepy dermatologii i alergologii
Marta Chełmińska, Krzysztof Specjalski, Anna Różyło, Agata Kołakowska, Ewa Jassem
Affiliations
Affiliations
- Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
- MEDI-LITE, Bielsko-Biala, Poland.
- Faculty of Electronics, Telecommunications and Informatics, Gdansk University of Technology, Gdansk, Poland.
PMID: 27279821
PMCID: PMC4884780 DOI: 10.5114/ada.2016.59154
Abstract
INTRODUCTION: Differentiating between cross-reactivity and double sensitization is still a challenging issue in allergology.
AIM: To differentiate cross-reactions accompanying latex allergy with the use of the ISAC test.
MATERIAL AND METHODS: Thirty-nine patients reporting immediate allergic reactions to latex were enrolled into the study (group A). The control group was comprised of 41 patients with allergic diseases not associated with latex (group B) and 20 healthy individuals (group C). Their history was recorded and skin prick tests were performed with latex, airborne and food allergens. Specific IgE against food allergens, latex (k82) and recombined latex allergens were determined. ImmunoCAP ISAC test was performed with 103 molecules.
RESULTS: Sensitization to latex was found by means of skin tests in 16 cases and sIgE against latex was revealed in 12 cases (including 10 positive in both SPT and sIgE). In the ISAC test antibodies against recombined latex allergens were found in 8 patients with rHev b 6 as the most common. All the patients positive for rHev b 1, 5, 6, 8 had allergy or asymptomatic sensitization to food allergens cross-reacting with latex. Some reactions could not have been differentiated due to the lack of allergens in the ISAC test. Others, not related to latex-fruits syndrome were explained by cross-reactivity with other profilins or PR-10 proteins.
CONCLUSIONS: ImmunoCAP ISAC test could be useful in differentiating between cross-reactions and double sensitizations. However, in the case of latex its advantages are limited due to a small panel of allergens.
Keywords: ISAC test; cross-reactivity; latex allergy
References
- Allergy. 2008 Nov;63(11):1521-8 - PubMed
- Allergy. 2007 Nov;62(11):1277-81 - PubMed
- Allergy. 2006 Sep;61(9):1146-7 - PubMed
- Clin Exp Allergy. 2010 Jun;40(6):911-21 - PubMed
- Allergy. 2000 Aug;55(8):712-7 - PubMed
- J Allergy Clin Immunol. 1992 Mar;89(3):759-68 - PubMed
- Clin Exp Allergy. 2003 Jul;33(7):971-7 - PubMed
- Clin Exp Allergy. 2010 Feb;40(2):348-58 - PubMed
- Anesthesiology. 1997 Mar;86(3):599-602 - PubMed
- Ann Allergy Asthma Immunol. 1996 Jan;76(1):37-40 - PubMed
- Allergy. 1997 Apr;52(4):404-10 - PubMed
- Int Arch Allergy Immunol. 2002 Jun;128(2):105-14 - PubMed
- Clin Exp Allergy. 2010 Feb;40(2):339-47 - PubMed
- Clin Exp Allergy. 1996 Apr;26(4):416-22 - PubMed
- Allergy. 1998 May;53(5):538-9 - PubMed
- Allergy. 1996 Sep;51(9):593-602 - PubMed
- J Investig Allergol Clin Immunol. 2010;20(2):129-38 - PubMed
- Ann Med. 1994 Aug;26(4):297-300 - PubMed
- Eur J Dermatol. 2010 Jan-Feb;20(1):54-61 - PubMed
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