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Balatti V, Acunzo M, Pekarky Y, et al. Novel mechanisms of regulation of miRNAs in CLL. Trends Cancer. 2016;2(3):134-143doi: 10.1016/j.trecan.2016.02.005.
Balatti, V., Acunzo, M., Pekarky, Y., & Croce, C. M. (2016). Novel mechanisms of regulation of miRNAs in CLL. Trends in cancer, 2(3), 134-143. https://doi.org/10.1016/j.trecan.2016.02.005
Balatti, Veronica, et al. "Novel mechanisms of regulation of miRNAs in CLL." Trends in cancer vol. 2,3 (2016): 134-143. doi: https://doi.org/10.1016/j.trecan.2016.02.005
Balatti V, Acunzo M, Pekarky Y, Croce CM. Novel mechanisms of regulation of miRNAs in CLL. Trends Cancer. 2016 Mar;2(3):134-143. doi: 10.1016/j.trecan.2016.02.005. PMID: 27213184; PMCID: PMC4874335.
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Trends Cancer. 2016 Mar;2(3):134-143. doi: 10.1016/j.trecan.2016.02.005.

Novel mechanisms of regulation of miRNAs in CLL.

Trends in cancer

Veronica Balatti, Mario Acunzo, Yuri Pekarky, Carlo M Croce

Affiliations

  1. Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Wexner Medical Center, The Ohio State University, Columbus, OH, USA.

PMID: 27213184 PMCID: PMC4874335 DOI: 10.1016/j.trecan.2016.02.005

Abstract

B-cell chronic lymphocytic leukemia (CLL) is the most common adult human leukemia. Although, the molecular alterations leading to CLL onset and progression are still under investigation (specifically, the interplay and exact role of oncogenes and tumor suppressors in CLL pathogenesis). MicroRNAs are small non-coding RNAs that regulate gene expression and are expressed in a tissue specific manner. Deregulation of microRNAs can alter expression levels of genes involved in the development and/or progression of tumors. In CLL, microRNAs can function as oncogenes or tumor suppressors. Here, we review the most recent findings on the role of microRNAs in the onset/progression of CLL, and how this knowledge can be used to identify new biomarkers and targets to treat this leukemia.

Keywords: CLL; miR-15/16; microRNA

References

  1. Blood. 2015 May 21;125(21):3297-305 - PubMed
  2. Cancer Cell. 2010 Jan 19;17(1):28-40 - PubMed
  3. Genes Immun. 2012 Apr;13(3):239-44 - PubMed
  4. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2555-60 - PubMed
  5. Blood. 2007 Jun 15;109(12):5079-86 - PubMed
  6. Oncotarget. 2010 Jul;1(3):224-7 - PubMed
  7. Blood. 2013 Sep 12;122(11):1891-9 - PubMed
  8. Leukemia. 2009 Mar;23(3):625-7 - PubMed
  9. Immunity. 2007 Dec;27(6):847-59 - PubMed
  10. Cell Cycle. 2007 Jul 1;6(13):1586-93 - PubMed
  11. Leukemia. 2014 Jan;28(1):98-107 - PubMed
  12. Leukemia. 2009 Jun;23(6):1159-63 - PubMed
  13. Jpn J Radiol. 2009 Jan;27(1):4-19 - PubMed
  14. Proc Natl Acad Sci U S A. 2006 May 2;103(18):7024-9 - PubMed
  15. Leukemia. 2015 Jan;29(1):86-95 - PubMed
  16. Nat Genet. 1999 Dec;23(4):474-8 - PubMed
  17. Blood. 2009 Apr 16;113(16):3801-8 - PubMed
  18. Proc Natl Acad Sci U S A. 2015 Feb 17;112(7):2169-74 - PubMed
  19. Int J Cancer. 2015 Sep 15;137(6):1352-61 - PubMed
  20. Mol Cell. 2007 Jun 8;26(5):745-52 - PubMed
  21. Curr Biol. 2007 Aug 7;17(15):1298-307 - PubMed
  22. EBioMedicine. 2015 Apr 29;2(6):572-82 - PubMed
  23. Mol Cancer. 2010 May 26;9:123 - PubMed
  24. PLoS One. 2015 Mar 20;10(3):e0118905 - PubMed
  25. Blood. 2010 Aug 12;116(6):945-52 - PubMed
  26. N Engl J Med. 2005 Oct 27;353(17):1793-801 - PubMed
  27. Sci China C Life Sci. 2009 Mar;52(3):224-31 - PubMed
  28. Nat Rev Clin Oncol. 2011 Jun 07;8(8):467-77 - PubMed
  29. Leukemia. 2006 Feb;20(2):280-5 - PubMed
  30. Cell Death Differ. 2015 Jan;22(1):6-11 - PubMed
  31. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15524-9 - PubMed
  32. J Hematol Oncol. 2014 Oct 23;7:79 - PubMed
  33. Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15805-10 - PubMed
  34. Mol Cancer. 2013 Dec 27;12:173 - PubMed
  35. Blood. 2003 Feb 15;101(4):1220-35 - PubMed
  36. Blood. 2015 Aug 27;126(9):1106-17 - PubMed
  37. Blood. 2012 Feb 2;119(5):1162-72 - PubMed
  38. Leukemia. 2012 Jul;26(7):1584-93 - PubMed
  39. Oncotarget. 2015 Aug 14;6(23):19807-18 - PubMed
  40. RNA. 2010 Apr;16(4):673-95 - PubMed
  41. PLoS One. 2011 Mar 08;6(3):e16956 - PubMed
  42. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18208-13 - PubMed
  43. Cancer Res. 2006 Dec 15;66(24):11590-3 - PubMed
  44. Cell. 2004 Jan 23;116(2):281-97 - PubMed
  45. Blood. 2001 Apr 1;97(7):2098-104 - PubMed
  46. Proc Natl Acad Sci U S A. 2010 Jul 6;107(27):12210-5 - PubMed
  47. Carcinogenesis. 2012 Jul;33(7):1294-301 - PubMed
  48. Blood. 2009 Sep 24;114(13):2589-97 - PubMed
  49. PLoS One. 2015 Oct 28;10(10):e0141429 - PubMed
  50. Leuk Lymphoma. 2013 Aug;54(8):1836-9 - PubMed
  51. Nat Immunol. 2008 Apr;9(4):405-14 - PubMed
  52. Blood. 2010 May 27;115(21):4191-7 - PubMed
  53. Blood. 2011 Sep 15;118(11):3072-9 - PubMed
  54. N Engl J Med. 2004 Aug 26;351(9):893-901 - PubMed
  55. Blood. 2014 Jul 24;124(4):546-54 - PubMed
  56. Genes Dev. 2009 Nov 15;23(22):2639-49 - PubMed
  57. Proc Natl Acad Sci U S A. 2006 May 16;103(20):7741-6 - PubMed
  58. Epigenetics. 2014 Jun;9(6):910-7 - PubMed
  59. JAMA. 2011 Jan 5;305(1):59-67 - PubMed
  60. Leuk Lymphoma. 2006 May;47(5):827-36 - PubMed
  61. Nat Rev Cancer. 2002 Sep;2(9):647-56 - PubMed
  62. Lancet. 2004 Jan 10;363(9403):105-11 - PubMed
  63. J Virol. 2010 Nov;84(22):11670-8 - PubMed
  64. Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):13944-9 - PubMed
  65. Mol Cell Biochem. 2012 Jun;365(1-2):203-10 - PubMed
  66. Proc Natl Acad Sci U S A. 2015 Sep 15;112(37):11636-41 - PubMed
  67. Infect Agent Cancer. 2010 Nov 22;5:22 - PubMed
  68. Proc Natl Acad Sci U S A. 2008 Apr 1;105(13):5166-71 - PubMed
  69. Proc Natl Acad Sci U S A. 2004 Aug 10;101(32):11755-60 - PubMed
  70. Haematologica. 2010 Jan;95(1):12-5 - PubMed
  71. N Engl J Med. 2000 Dec 28;343(26):1910-6 - PubMed

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