Display options
Share it on

Pharmaceuticals (Basel). 2016 May 19;9(2). doi: 10.3390/ph9020028.

Targeted Therapies for the Treatment of Pediatric Non-Hodgkin Lymphomas: Present and Future.

Pharmaceuticals (Basel, Switzerland)

Caryn E Sorge, Jenny K McDaniel, Ana C Xavier

Affiliations

  1. Department of Pediatrics, Division of Pediatric Hematology/Oncology, Children's Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL 35233, USA. [email protected].
  2. Department of Pediatrics, Division of Pediatric Hematology/Oncology, Children's Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL 35233, USA. [email protected].
  3. Department of Pediatrics, Division of Pediatric Hematology/Oncology, Children's Hospital of Alabama, University of Alabama at Birmingham, Birmingham, AL 35233, USA. [email protected].

PMID: 27213405 PMCID: PMC4932546 DOI: 10.3390/ph9020028

Abstract

Pediatric Non-Hodgkin Lymphomas (NHL) are a diverse group of malignancies and as such treatment can vary based on the different biological characteristics of each malignancy. Significant advancements are being made in the treatment and outcomes of this group of malignancies. This is in large part due to novel targeted drug therapies that are being used in combination with traditional chemotherapy. Here, we discuss several new lines of therapy that are being developed or are in current use for pediatric patients with NHL.

Keywords: Non-Hodgkin lymphoma; pediatric; targeted therapies

References

  1. Clin Cancer Res. 2003 Sep 1;9(10 Pt 1):3578-88 - PubMed
  2. Semin Oncol. 2002 Feb;29(1 Suppl 2):2-9 - PubMed
  3. Pediatr Nephrol. 2005 Nov;20(11):1660-3 - PubMed
  4. Leukemia. 2013 Apr;27(5):1174-7 - PubMed
  5. J Clin Oncol. 2015 Aug 10;33(23):2492-9 - PubMed
  6. Blood. 2007 Apr 1;109(7):2773-80 - PubMed
  7. Cell Cycle. 2010 May;9(9):1830-8 - PubMed
  8. J Clin Oncol. 2001 Jan 15;19(2):389-97 - PubMed
  9. Curr Opin Pediatr. 2008 Feb;20(1):17-22 - PubMed
  10. Pediatr Blood Cancer. 2005 Jan;44(1):70-6 - PubMed
  11. Mol Cancer Res. 2015 Apr;13(4):775-83 - PubMed
  12. Blood. 2001 Nov 1;98(9):2865-8 - PubMed
  13. Blood. 1994 Jan 15;83(2):435-45 - PubMed
  14. J Clin Oncol. 2012 Aug 1;30(22):2753-9 - PubMed
  15. J Clin Oncol. 2006 Aug 1;24(22):3678-85 - PubMed
  16. J Clin Oncol. 2005 Jun 10;23(17):3923-31 - PubMed
  17. Nature. 2008 Oct 16;455(7215):971-4 - PubMed
  18. N Engl J Med. 2012 Jun 28;366(26):2443-54 - PubMed
  19. J Pediatr Hematol Oncol. 2014 Mar;36(2):e85-7 - PubMed
  20. J Clin Oncol. 2012 Feb 20;30(6):631-6 - PubMed
  21. Pediatr Blood Cancer. 2009 Feb;52(2):177-81 - PubMed
  22. Leuk Lymphoma. 2016 Oct;57(10 ):2359-69 - PubMed
  23. J Cell Biochem. 2005 Oct 1;96(2):293-304 - PubMed
  24. J Clin Oncol. 2005 May 20;23(15):3396-403 - PubMed
  25. J Clin Oncol. 2002 May 15;20(10 ):2453-63 - PubMed
  26. Bone Marrow Transplant. 2001 Feb;27(3):329-32 - PubMed
  27. Blood. 1993 Apr 15;81(8):2003-6 - PubMed
  28. Cancer Res. 2003 Aug 1;63(15):4460-71 - PubMed
  29. Cancer Res. 1999 Jun 15;59(12):2776-80 - PubMed
  30. Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13075-80 - PubMed
  31. Pediatr Blood Cancer. 2015 Jul;62(7):1176-83 - PubMed
  32. Br J Haematol. 2014 Nov;167(3):394-401 - PubMed
  33. J Clin Oncol. 2005 May 20;23(15):3376-82 - PubMed
  34. Bioconjug Chem. 2006 Jan-Feb;17(1):114-24 - PubMed
  35. J Clin Oncol. 2012 Jun 20;30(18):2183-9 - PubMed
  36. Am J Health Syst Pharm. 2014 Sep 1;71(17):1430 - PubMed
  37. Cytotherapy. 2014 Oct;16(10):1431-40 - PubMed
  38. Exp Hematol. 2005 Jan;33(1):53-61 - PubMed
  39. N Engl J Med. 2015 Jan 22;372(4):311-9 - PubMed
  40. Br J Haematol. 2010 Aug;150(3):345-51 - PubMed
  41. J Clin Oncol. 1999 Jan;17(1):268-76 - PubMed
  42. Blood. 2010 Oct 21;116(16):3013-22 - PubMed
  43. Nat Clin Pract Oncol. 2005 Mar;2(3):150-7 - PubMed
  44. Clin Cancer Res. 2015 Jun 15;21(12):2666-70 - PubMed
  45. Clin Cancer Res. 2004 Oct 15;10(20):7063-70 - PubMed
  46. N Engl J Med. 2011 Feb 24;364(8):775-6 - PubMed
  47. Clin Cancer Res. 2003 Mar;9(3):1136-44 - PubMed
  48. Lancet Oncol. 2013 Dec;14 (13):1348-56 - PubMed
  49. Ther Clin Risk Manag. 2007 Dec;3(6):1135-41 - PubMed
  50. Apoptosis. 2004 Mar;9(2):149-55 - PubMed
  51. J Clin Oncol. 2009 Jul 10;27(20):3363-9 - PubMed
  52. Blood. 2003 Sep 1;102(5):1842-8 - PubMed
  53. Semin Oncol. 2010 Oct;37(5):430-9 - PubMed
  54. Blood. 2003 Mar 15;101(6):2377-80 - PubMed
  55. Semin Oncol. 2002 Feb;29(1 Suppl 2):41-7 - PubMed
  56. Nat Rev Drug Discov. 2006 Sep;5(9):769-84 - PubMed
  57. Cancer Res. 2015 Jun 1;75(11):2146-50 - PubMed
  58. Cancer. 2006 Apr 1;106(7):1569-80 - PubMed
  59. J Clin Oncol. 2012 Feb 1;30(4):387-93 - PubMed
  60. Blood. 2006 Apr 15;107(8):3058-64 - PubMed
  61. Blood. 2003 Jan 15;101(2):391-8 - PubMed
  62. Cancer Res. 2008 Jul 1;68(13):4971-6 - PubMed
  63. Lancet Oncol. 2013 May;14(6):472-80 - PubMed
  64. J Hematol Oncol. 2014 Jan 23;7:11 - PubMed
  65. Br J Haematol. 2005 Dec;131(5):624-7 - PubMed
  66. N Engl J Med. 2010 Nov 4;363(19):1812-21 - PubMed
  67. J Clin Oncol. 2000 Mar;18(5):995-1003 - PubMed
  68. Blood. 2011 Jan 13;117(2):591-4 - PubMed
  69. Leuk Res. 2012 Jun;36(6):773-8 - PubMed
  70. Clin Cancer Res. 2006 Sep 15;12(18):5329-35 - PubMed
  71. J Clin Oncol. 2001 May 1;19(9):2390-6 - PubMed
  72. Blood. 2012 Jul 12;120(2):285-90 - PubMed
  73. Clin Cancer Res. 2007 Sep 15;13(18 Pt 2):5652s-5660s - PubMed
  74. Pediatr Blood Cancer. 2008 Jan;50(1):37-45 - PubMed
  75. Blood. 1998 Sep 15;92(6):1927-32 - PubMed
  76. Mod Pathol. 2007 Mar;20(3):320-5 - PubMed
  77. Pediatr Blood Cancer. 2010 Aug;55(2):254-9 - PubMed
  78. Lancet Oncol. 2006 May;7(5):379-91 - PubMed
  79. J Clin Oncol. 2010 Jul 1;28(19):3115-21 - PubMed
  80. N Engl J Med. 2012 Jun 28;366(26):2455-65 - PubMed
  81. Clin Adv Hematol Oncol. 2003 May;1(5):314-7 - PubMed
  82. Blood Cancer J. 2015 Oct 16;5:e357 - PubMed
  83. Int J Oncol. 2003 Feb;22(2):319-24 - PubMed
  84. J Clin Oncol. 2002 Aug 1;20(15):3262-9 - PubMed

Publication Types