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de Souza Silva MA, Mattern C, Decheva C, et al. Intranasal Dopamine Reduces In Vivo [(123)I]FP-CIT Binding to Striatal Dopamine Transporter: Correlation with Behavioral Changes and Evidence for Pavlovian Conditioned Dopamine Response. Front Behav Neurosci. 2016;10:80doi: 10.3389/fnbeh.2016.00080.
de Souza Silva, M. A., Mattern, C., Decheva, C., Huston, J. P., Sadile, A. G., Beu, M., Müller, H. W., & Nikolaus, S. (2016). Intranasal Dopamine Reduces In Vivo [(123)I]FP-CIT Binding to Striatal Dopamine Transporter: Correlation with Behavioral Changes and Evidence for Pavlovian Conditioned Dopamine Response. Frontiers in behavioral neuroscience, 1080. https://doi.org/10.3389/fnbeh.2016.00080
de Souza Silva, Maria A, et al. "Intranasal Dopamine Reduces In Vivo [(123)I]FP-CIT Binding to Striatal Dopamine Transporter: Correlation with Behavioral Changes and Evidence for Pavlovian Conditioned Dopamine Response." Frontiers in behavioral neuroscience vol. 10 (2016): 80. doi: https://doi.org/10.3389/fnbeh.2016.00080
de Souza Silva MA, Mattern C, Decheva C, Huston JP, Sadile AG, Beu M, Müller HW, Nikolaus S. Intranasal Dopamine Reduces In Vivo [(123)I]FP-CIT Binding to Striatal Dopamine Transporter: Correlation with Behavioral Changes and Evidence for Pavlovian Conditioned Dopamine Response. Front Behav Neurosci. 2016 Apr 22;10:80. doi: 10.3389/fnbeh.2016.00080. eCollection 2016. PMID: 27148001; PMCID: PMC4840254.
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Front Behav Neurosci. 2016 Apr 22;10:80. doi: 10.3389/fnbeh.2016.00080. eCollection 2016.

Intranasal Dopamine Reduces In Vivo [(123)I]FP-CIT Binding to Striatal Dopamine Transporter: Correlation with Behavioral Changes and Evidence for Pavlovian Conditioned Dopamine Response.

Frontiers in behavioral neuroscience

Maria A de Souza Silva, Claudia Mattern, Cvetana Decheva, Joseph P Huston, Adolfo G Sadile, Markus Beu, H-W Müller, Susanne Nikolaus

Affiliations

  1. Center for Behavioral Neuroscience, Institute of Experimental Psychology, Heinrich-Heine University Düsseldorf, Germany.
  2. M et P Pharma AGEmmetten, Switzerland; Oceanographic Center, Nova Southeastern UniversityFort Lauderdale, FL, USA.
  3. Department of Experimental Medicine, School of Medicine, II University of Naples Naples, Italy.
  4. Clinic of Nuclear Medicine, University Hospital Düsseldorf Düsseldorf, Germany.

PMID: 27148001 PMCID: PMC4840254 DOI: 10.3389/fnbeh.2016.00080

Abstract

THE RESULTS: (a) demonstrate a direct central action of intranasally applied DA on the DAT in the dorsal striatum, indicating enhanced DA availability; and (b) provide first evidence of a Pavlovian conditioned DA response at the DAT. The latter results have relevance to understanding neurochemical mechanisms that underlie placebo action in the treatment of Parkinsonian patients.

Keywords: Pavlovian conditioning; dopamine; dopamine transporter; intranasal administration; placebo; small animal SPECT

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