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Krause K, Amer AO. Caspase Exploitation by Legionella pneumophila. Front Microbiol. 2016;7:515doi: 10.3389/fmicb.2016.00515.
Krause, K., & Amer, A. O. (2016). Caspase Exploitation by Legionella pneumophila. Frontiers in microbiology, 7515. https://doi.org/10.3389/fmicb.2016.00515
Krause, Kathrin, and Amer, Amal O. "Caspase Exploitation by Legionella pneumophila." Frontiers in microbiology vol. 7 (2016): 515. doi: https://doi.org/10.3389/fmicb.2016.00515
Krause K, Amer AO. Caspase Exploitation by Legionella pneumophila. Front Microbiol. 2016 Apr 13;7:515. doi: 10.3389/fmicb.2016.00515. eCollection 2016. PMID: 27148204; PMCID: PMC4829591.
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Front Microbiol. 2016 Apr 13;7:515. doi: 10.3389/fmicb.2016.00515. eCollection 2016.

Caspase Exploitation by Legionella pneumophila.

Frontiers in microbiology

Kathrin Krause, Amal O Amer

Affiliations

  1. Department of Microbial Infection and Immunity, The Ohio State University Columbus, OH, USA.

PMID: 27148204 PMCID: PMC4829591 DOI: 10.3389/fmicb.2016.00515

Abstract

Legionella pneumophila remains a major health concern, especially for hospitalized patients. L. pneumophila in the environment can survive extracellular or as protozoan parasite within amoeba. After human infection it efficiently replicates in alveolar macrophages without activating inflammasome assembly and cleavage of caspase-1. In contrast murine macrophages actively recognize intracellular L. pneumophila via inflammasome components which initiate pro-inflammatory cytokine secretion, phagosomal maturation and pyroptotic cell death thereby leading to bacterial restriction. During this process flagellin-dependent and -independent signaling pathways trigger the canonical as well as the non-canonical inflammasome. This review describes the current knowledge about L. pneumophila-induced inflammasome pathways in permissive and restrictive host cells.

Keywords: Legionella pneumophila; NOD like receptors; caspases; cell death mechanisms; phagosomal maturation

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