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Dantuma NP, Pfeiffer A. Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks. Front Genet. 2016;7:58doi: 10.3389/fgene.2016.00058.
Dantuma, N. P., & Pfeiffer, A. (2016). Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks. Frontiers in genetics, 758. https://doi.org/10.3389/fgene.2016.00058
Dantuma, Nico P, and Pfeiffer, Annika. "Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks." Frontiers in genetics vol. 7 (2016): 58. doi: https://doi.org/10.3389/fgene.2016.00058
Dantuma NP, Pfeiffer A. Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks. Front Genet. 2016 Apr 11;7:58. doi: 10.3389/fgene.2016.00058. eCollection 2016. PMID: 27148355; PMCID: PMC4826866.
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Front Genet. 2016 Apr 11;7:58. doi: 10.3389/fgene.2016.00058. eCollection 2016.

Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks.

Frontiers in genetics

Nico P Dantuma, Annika Pfeiffer

Affiliations

  1. Department of Cell and Molecular Biology, Karolinska Institutet Stockholm, Sweden.

PMID: 27148355 PMCID: PMC4826866 DOI: 10.3389/fgene.2016.00058

Abstract

Ubiquitin and the ubiquitin-like modifier SUMO are intimately connected with the cellular response to various types of DNA damage. A striking feature is the local accumulation of these proteinaceous post-translational modifications in the direct vicinity to DNA double-strand breaks, which plays a critical role in the formation of ionizing radiation-induced foci. The functional significance of these modifications is the coordinated recruitment and removal of proteins involved in DNA damage signaling and repair in a timely manner. The central orchestrators of these processes are the ubiquitin and SUMO ligases that are responsible for accurately tagging a broad array of chromatin and chromatin-associated proteins thereby changing their behavior or destination. Despite many differences in the mode of action of these enzymes, they share some striking features that are of direct relevance for their function in the DNA damage response. In this review, we outline the molecular mechanisms that are responsible for the recruitment of ubiquitin and SUMO ligases and discuss the importance of chromatin proximity in this process.

Keywords: DNA damage; DNA double-strand breaks; SUMO; chromatin; ubiquitin

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